Project Grant R21NS145426
- This $453,033 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Case Western Reserve University to investigate the role of microglia-mediated glycosaminoglycan catabolism in the neuropathology of Mucopolysaccharidosis VII (MPS VII). The key objectives are to develop new genetic tools to conditionally ablate beta-glucuronidase...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,270,237 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, effective August 1, 2025, will support a program to investigate the pathogenic mechanisms associated with neural disease in Congenital Disorders of Glycosylation (CDG). The program will utilize zebrafish, Drosophila, and human...
- This federal Project Grant award, valued at $147,486, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of this award is to investigate the function of a ciliary protein in neural development, with a focus on uncovering novel molecular mechanisms involved in synapse formation that may be relevant to neurological disorders. Using C. elegans as...
- This federal Project Grant award of $431,676 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to investigate the role of the glucocorticoid receptor (GR) and its interaction with the cytochrome P450 (CYP) and P-glycoprotein (PGP) pathways in regulating anti-seizure medication bioavailability across the blood-brain barrier in drug-resistant epilepsy with...
- This $128,802 Project Grant was awarded on January 6, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding supports a research project by Case Western Reserve University to define the function of a novel insulin-like growth factor binding protein, named Crimpy, in the central nervous system (CNS) development and function. The project...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $377,262 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The University of Kentucky Research Foundation. The grant, awarded on August 15, 2025, supports research to investigate the mechanism underlying sphingoid base-induced neurotoxicity in neurodegenerative diseases. Specifically, the project will use a transgenic mouse model to dissect the...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $236,668.00 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on the impact of the C9ORF72-associated poly (GR) protein on the structure and function of the BAF chromatin remodeling complex. The research aims to...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $442,750 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Case Western Reserve University. The funding supports research to investigate the role of the CCPG1 protein, an endoplasmic reticulum (ER)-phagy receptor, in maintaining the proteostasis of gamma-aminobutyric acid type A (GABAA) receptors in the central nervous system. The research aims to understand how CCPG1 directs aggregation-prone GABAA receptor variants in the ER to the ER-phagy degradation pathway, and how loss of CCPG1 function leads to protein aggregation and potential neurological diseases. The award period is from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.8k | 7/31/25 |