The federal Project Grant award K01NS136791, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to elucidate how interactions between the arginine-containing dipeptide repeat protein poly(GR) and the BRG1/BRM associated factor (BAF) chromatin remodeling complex impact chromatin structure and gene expression in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The $236,668 award, with a project period from December 15, 2024 to November 30, 2029, will enable the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to use cross-link mass spectrometry, chromatin accessibility profiling, and gene expression analysis to gain a comprehensive understanding of chromatin dysregulation in C9ORF72-related FTD. The results from this project could provide insights into the pathogenesis of these fatal neurodegenerative diseases.
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