Project Grant P01NS138003
- The federal Project Grant award of $719,498 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) supports research at The Children's Hospital of Philadelphia Research Institute to elucidate the neurobiological functions of glycosylation and its role in congenital disorders of glycosylation (CDG). The research aims to identify the neurological impacts of disrupted...
- This federal Project Grant award of $169,000 from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) will support the development of a comprehensive, open-source, and user-friendly online platform for neurometabolic diseases. The platform will include clinical, biochemical, radiological, and therapeutic data on over 1,600 known neurometabolic diseases. This initiative aims to enhance understanding, clinical management, and research insights into these rare genetic...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This $491,163.00 Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research conducted by the Icahn School of Medicine at Mount Sinai focused on understanding the role of plasma membrane properties and cytoskeleton mechanics in regulating neuroprogenitor cell differentiation and neurogenesis during...
- This federal Project Grant award of $629,796 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to track, quantify, and localize key metabolic pathways that regulate brain growth during development. Specifically, the project will investigate two critical metabolic switches in the developing mouse brain: (1) a shift from glycolytic to...
- This federal Project Grant award of $364,448.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) focuses on investigating the neural functions of glycoprotein sialylation. The research aims to reveal sialylation-mediated mechanisms of glia-neuron coupling, elucidate the role of sialylation in promoting neuronal viability and resistance to oxidative stress, and characterize...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $897,250 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to St. Jude Children's Research Hospital Inc. The grant will fund an 8-year research program to investigate the physiological functions of biomolecular condensates, how they establish distinct identities, and the relationship between condensate dysfunction and the pathogenesis of neurological...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $442,750 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Case Western Reserve University. The funding supports research to investigate the role of the CCPG1 protein, an endoplasmic reticulum (ER)-phagy receptor, in maintaining the proteostasis of gamma-aminobutyric acid type A (GABAA) receptors in the central nervous system. The research aims to...
- This federal Project Grant award, valued at $643,377.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate cellular mechanisms of enteric nervous system damage in CLN2 disease, a rare neurodegenerative lysosomal storage disorder. The research aims to better understand how lysosomal dysfunction leads to...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,270,237 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, effective August 1, 2025, will support a program to investigate the pathogenic mechanisms associated with neural disease in Congenital Disorders of Glycosylation (CDG). The program will utilize zebrafish, Drosophila, and human neural models to elucidate how defects in protein glycosylation and sugar phosphate metabolism impact neurons and glia during cerebellar development. The overall goal is to improve the limited understanding of CDG pathogenesis and accelerate the development of therapies for these devastating neurological conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 7/30/25 |