Project Grant R01NS138293
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
- This Project Grant award of $426,313, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research at The Johns Hopkins University to investigate the signaling pathways that disrupt neurofilament (NF) phosphorylation dynamics and lead to NF hyperphosphorylation, a pathology associated with neurodegenerative diseases such as amyotrophic lateral...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Kenyon College a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $454,424 grant, effective April 1, 2025 through March 31, 2028, aims to characterize the cellular and molecular mechanisms of Schwann cell demyelination and identify factors that promote peripheral remyelination using a novel larval zebrafish model. The project will test...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $190,485 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Trustees of Indiana University (Indiana University Indianapolis) on February 4, 2025. The grant supports research to investigate the molecular mechanisms underlying differentiation failure in neuroepithelial stem cells with NF2 gene mutations, with the goal of identifying novel therapeutic...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the U.S. Department of Health and Human Services, awarded a $663,942 Project Grant to Yale University under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant, awarded on July 25, 2025 with an ultimate completion date of June 30, 2030, supports research to examine the interplay between the synaptic proteins complexin and synaptotagmin and their...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,830,581 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The grant supports in-depth characterization of the mechanism of action of a new macrocycle molecule called RAPIREON, which selectively activates the nuclease activity of the IRE1 protein in the unfolded protein response (UPR) pathway....
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $897,250 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to St. Jude Children's Research Hospital Inc. The grant will fund an 8-year research program to investigate the physiological functions of biomolecular condensates, how they establish distinct identities, and the relationship between condensate dysfunction and the pathogenesis of neurological...
- This $441,195 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to define molecular pathways that drive neurodegeneration and identify ways to block axon and synapse loss in patients. The project aims to build on prior work identifying the SARM1 protein as a key regulator of axon degeneration, and to explore the role of the DWNK...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $377,262 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The University of Kentucky Research Foundation. The grant, awarded on August 15, 2025, supports research to investigate the mechanism underlying sphingoid base-induced neurotoxicity in neurodegenerative diseases. Specifically, the project will use a transgenic mouse model to dissect the autonomous neuronal effects of elevated sphingoid bases on gene expression and cellular pathways in the brain. The research aims to address critical knowledge gaps in understanding how disruptions in sphingolipid metabolism contribute to neurological disorders such as Alzheimer's disease. This project leverages the expertise of the University of Kentucky Research Foundation in advanced neuroscience research to advance understanding of brain health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $377.3k | 8/12/25 |