This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
This federal Project Grant award of $606,029.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the neurocircuitry underlying motivated reward-seeking behavior in response to stress. The key goals of the research are to: 1) Determine if a subpopulation of GABAergic neurons in the medial habenulo-interpeduncular (MHB-IPN) axis...
This Project Grant award of $360,000 from the National Science Foundation's Biological Sciences (CFDA 47.074) program aims to investigate the role of neuron-neuron communication, particularly neurotransmitter-based and neuropeptidergic chemical neurotransmission, in the post-mitotic maturation of neurons during postnatal development. The research will utilize the model organism Caenorhabditis elegans and leverage advanced genetics, behavioral assays, microscopy, and genomics tools to examine the...
This Project Grant award of $742,484 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will fund research to characterize a genetic mouse model and delineate its function in the brain. The award to the University of Alabama at Birmingham will span 5 years from January 2025 to October 2029. The research aims to identify novel downstream targets in the mammalian brain, elucidate behavioral outcome measures, and generate new hypotheses...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $828,335 to the University of Chicago to investigate the roles of inhibitory and disinhibitory neural circuits in the formation, stabilization, and competition of neural assemblies in the cortex. The project aims to experimentally test theoretical...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the basal ganglia network neurophysiology of depression in Parkinson's disease (PD). The objective is to identify basal ganglia neural activity associated with depression in PD, determine the brain regions and networks involved, and determine brain...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will provide $671,340 to the University of Alabama at Birmingham (UAB) over a 5-year period starting May 1, 2025. The objective of this research project is to investigate the cellular mechanisms within the amygdala that drive shifts in valence processing (the brain's perception of positive and negative stimuli) across the female reproductive cycle....
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by the Research Foundation For Mental Hygiene, Inc. (RFMH) to examine the microcircuitry of cue and spatial representations in the dentate gyrus region of the hippocampus. The $489,197 award, spanning July 1, 2025 to June 30, 2030, will leverage in vivo...