This $360,000 Project Grant awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program aims to uncover the role of neuron-neuron communication in the post-mitotic maturation of neurons during postnatal development. Utilizing the model organism Caenorhabditis elegans, the University of Alabama at Birmingham (UAB) will leverage advanced genetics, behavioral assays, microscopy, and genomics tools to examine the molecular and functional maturation of neurons. The project seeks to delineate the interplay between extrinsic environmental stimuli and intrinsic genetic mechanisms in regulating neuronal maturation, with potential implications for understanding brain function and disease across species. This 5-year award, starting on April 1, 2025, will provide critical insights into neuronal development and foster the training of future scientists through hands-on research experiences and communication skill development.
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