This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by the Research Foundation For Mental Hygiene, Inc. (RFMH) to examine the microcircuitry of cue and spatial representations in the dentate gyrus region of the hippocampus. The $489,197 award, spanning July 1, 2025 to June 30, 2030, will leverage in vivo calcium imaging, population decoding, and optogenetic circuit analysis techniques to better understand how the dentate gyrus integrates sensory cue and self-motion information to form spatial representations, and how these processes may be impacted in neurological disorders affecting spatial navigation and memory. The research aims to advance scientific understanding of hippocampal function and its role in cognition, with potential implications for improving diagnosis and treatment of conditions like Alzheimer's disease and age-related dementia.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $489.2k | 6/27/25 |