This Project Grant award of $697,907.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding supports research at Thomas Jefferson University's Sidney Kimmel Medical College to investigate the involvement of the C-JUN/transposable element (TE)/cGAS/STING pathway in C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research into the mechanisms and toxicity of chimeric dipeptide repeat (CDPR) proteins in C9ALS/FTD, a genetic form of amyotrophic lateral sclerosis and frontotemporal dementia. The $1,938,189 award to Emory University aims to: 1) identify the complexity, extent, and mechanism of CDPR pathology in C9ALS/FTD; 2) determine the molecular consequences and neuronal toxicity of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $461,900.00 to Pennsylvania State University to study the role of the TDP-43 protein in muscle degeneration associated with amyotrophic lateral sclerosis (ALS) and other neuromuscular disorders. The key objectives are to: 1) Identify TDP-43 translation targets in Drosophila muscle models using overexpression and loss-of-function approaches, and 2) Validate candidate TDP-43 target genes in fly...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded a $1,138,538 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Mayo Clinic Jacksonville, a nonprofit healthcare organization, to conduct research on the molecular mechanisms and therapeutic interventions related to frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The research aims to explore the...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and validation of Synapticure Inc.'s novel 3D in vitro "Cortical Brain Spheroids" (CBS) platform for modeling genetic and sporadic subtypes of Frontotemporal Dementia (FTD). The $1,253,527 award, with an ultimate completion date of April 30,...
This Project Grant award, R21AG094047, was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $442,750 award, with a period of performance from May 2025 to April 2027, supports research by Case Western Reserve University (CWRU) to develop synthetic replicas of TDP-43 protein filaments associated with frontotemporal dementia and amyotrophic lateral sclerosis. The goal is to establish an experimental model for generating these...
The National Institutes of Health (NIH), through the National Institute on Aging (CFDA 93.866 Aging Research program), awarded a $803,111 Project Grant to The Trustees of the University of Pennsylvania. The grant, effective from December 15, 2024 to November 30, 2029, will support a comprehensive study to model and contrast the microscopic, mesoscopic and macroscopic regional progression of neuroinflammation, abnormal iron accumulation and neurodegeneration in human brain tissue from patients...
This federal Project Grant award for $2,307,075.00, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports innovative research aimed at defining novel mechanisms of neurodegenerative diseases and devising potential therapeutic strategies. The primary recipient, The Leland Stanford Junior University, will conduct genome-wide modifier screens in human...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports scientific research into the neuropathological features and molecular signatures of Frontotemporal Lobar Degeneration with Transactive Response DNA-Binding Protein Type C (FTLD-TDP Type C). The $786,632 award to Northwestern University, with a performance period from December 1, 2024 to November 30, 2029, will expand on prior discoveries regarding the impact of FTLD-TDP Type C on the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $630,496 to the J. David Gladstone Institutes in San Francisco, CA to conduct research on the underlying mechanisms of proteostasis dysfunction and neuroinflammation in frontotemporal dementia (FTD) caused by GRN haploinsufficiency. The study aims to better define alterations in proteostasis, autophagy, and lysosomal function in FTD neurons, microglia, and astrocytes to determine if...