Project Grant R21NS138593

Award Date 8/1/25
Completion Date 7/31/27
Dollars Obligated $548K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
North Carolina, USA
Similar Awards
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $603,406 to Research Triangle Institute (RTI International) to develop GPR139 antagonists for enhancing the analgesic efficacy of opioid medicines and reducing opioid-related side effects. The project aims to optimize potency, selectivity, and drug-like properties of GPR139...
This federal Project Grant award of $614,009, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at understanding the molecular mechanisms of oligodendrocyte myelination and remyelination. The research, conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, focuses on identifying critical factors that promote myelin...
This $1,511,970 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of selective GPR34 antagonists for the treatment of neuropathic pain. The award aims to identify CNS-active GPR34 hits that can be further developed into novel GPR34 antagonists as potential drug candidates for neuropathic pain. Key products and services include: 1) Synthesis and testing of novel...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $506,083.00 to Artificial Axon Labs Inc. to develop a novel biomimetic 3D-printed drug discovery platform called "Artificial Axons" for screening remyelinating compounds to treat multiple sclerosis (MS) and other myelin diseases. The key products and services...
This Project Grant award of $534,964.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development of an in vitro platform to investigate the role of matrix metalloproteinase-9 (MMP-9) in the breakdown of the blood-brain barrier and extracellular matrix in multiple sclerosis. The research team at Michigan State University will integrate real-time...
This $233,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research at The Washington University to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging to non-invasively study the role of lactate metabolism and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing a novel drug candidate to treat demyelinating neuropathies. The $352,073 award will support rigorous in vivo testing of the experimental ABCA1 agonist drug, CS6253, in validated mouse models of hereditary peripheral nerve disorders characterized by impaired...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $107,279 to Research Triangle Institute (RTI International) to identify novel small molecule orexin agonists via high-throughput screening of their in-house compound library. The goal is to discover orexin agonists that could potentially be developed into pharmacotherapies for...
This federal Project Grant award, totaling $653,192.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports a longitudinal study on non-invasive imaging of pathological fibrin deposition and its effects on progressive neurodegeneration in the human brain. The study, conducted by the primary awardee The General Hospital Corporation (doing business as...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $431,750.00 to support research aimed at overexpressing the CYP2C11 enzyme in peri-lesion astrocytes of mice with multi-infarct dementia (MID). The goal is to enhance cerebral blood flow and suppress neuroinflammation, potentially improving cognitive function in this prevalent...

This Project Grant award of $547,846 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will support research to optimize and characterize small molecule GPR17 antagonists for potential treatment of multiple sclerosis (MS). The key objectives are to: 1) synthesize at least 100 novel analogs of the lead compound SN-191 through structural modifications, 2) evaluate the synthesized compounds for GPR17 potency and selectivity over CYSLT1, and 3) assess selected analogs for their ability to promote oligodendrocyte myelination using in vitro assays. This collaborative research project between chemistry and pharmacology experts aims to identify potent and selective GPR17 antagonists that could serve as valuable tools to study GPR17 biology and potentially lead to new drug discovery opportunities for severe demyelinating diseases like MS. The project will be conducted by the prime awardee, Research Triangle Institute (RTI International), over the period of August 1, 2025 to July 31, 2027.

Generated 8/5/25, 3:25 AM