Project Grant R21NS136890
- This federal Project Grant award of $501,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to determine the mechanisms of dopamine transmission in the brain and how it regulates motor function and learning. The research aims to understand how different dopamine signals mediate transmission and impact aspects of motor activity and learning,...
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
- This federal Project Grant award of $220,260.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of the grant is to investigate the role of the RNA-binding protein ELAVL3 in regulating glutamate and dopamine receptor signaling in the striatal neurons of the brain, with the goal of understanding the molecular mechanisms underlying striatal...
- This $112,158 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in basal ganglia neural activity associated with depression in Parkinson's disease (PD) patients. The research aims to determine the specific brain regions and networks involved, as well as evaluate the effects of deep brain stimulation (DBS)...
- This federal Project Grant award for $101,451 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to characterize genes that regulate the regeneration of dopaminergic neurons in the planarian brain. The research aims to establish a timeline of dopaminergic neuron maturation and regeneration, uncover the cellular mechanism through which the LMO3...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel gene therapy approach to reduce neurotoxicity in Parkinson's disease. The $1,009,212 award to the Van Andel Research Institute in Grand Rapids, MI will fund pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to enhance the activity of the...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $529,878 to Boston Children's Hospital from December 1, 2024 to November 30, 2029. The project aims to investigate the molecular mechanisms underlying the desensitization of dopamine receptors that occurs after goal-directed behaviors, such as mating in Drosophila. This...
- This $147,486 federal project grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by Yale University to explore disruptions in dopamine transporter (DAT) recycling and trafficking as potential early pathomechanisms in Parkinson's disease. The project aims to use live-cell and super-resolution imaging techniques to measure DAT endocytosis and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $2,723,954.00 to the University of Alabama at Birmingham (UAB) from June 1, 2025 to May 31, 2027. The grant supports research focused on understanding the effects of 14-3-3θ protein phosphorylation on vesicular transport and alpha-synuclein aggregation, which are key mechanisms...
- This federal Project Grant award of $613,786.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to elucidate the molecular, cellular, and physiological consequences of D1 dopamine receptor (D1DR) signaling from both the plasma membrane and Golgi compartments in primary medium spiny neurons. The research aims to advance understanding of the role of compartmentalized D1DR signaling in the neurobiology...
This Project Grant award of $422,125 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the fundamental roles of the DNAJC12 protein in dopamine production and brain function. The research aims to specifically ablate DNAJC12 in dopaminergic neurons in order to ascertain the effects of this gene dysfunction on dopamine synthesis, physiology, and related behavior. The findings may reveal novel approaches to maintain or restore brain dopamine, with potential applications for disorders like Parkinson's disease. The award has a performance period from August 15, 2025 to July 31, 2027 and will be carried out by researchers at the University of Florida.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.1k | 8/12/25 |