The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $481,250 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to President and Fellows of Harvard College. The grant's objective is to develop a synthetic biological system that can manipulate subcellular RNAs and proteins in a subtype- and context-specific manner within neurons. This system aims to enable novel investigations of how subcellular...
The National Institute of Mental Health (NIMH) awarded a $857,216 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct a longitudinal study on the neurodevelopmental trajectories and social determinants leading to early symptoms of Attention Deficit Hyperactivity Disorder (ADHD) and Disruptive Behaviors (DB) in a diverse cohort of infants and preschoolers. The study aims to characterize...
This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to uncover the neural circuit mechanisms that generate dopamine neuron activity and dopamine reward prediction error (RPE) signals. The $656,073 award to President and Fellows of Harvard College will support three key research objectives: Examining the roles of glutamate and GABA inputs to dopamine neurons in generating dopamine RPE...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $230,904 to support research aimed at identifying novel molecular genetic causes of infantile epilepsies and evaluating the clinical and family impact of genetic diagnoses. The grant recipient, The Children's Hospital Corporation (doing business as Boston Children's...
This $2,535,618 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to advance the understanding of the genomic mechanisms underlying primary attention-deficit/hyperactivity disorder (ADHD) in families. The key products and services to be delivered through this 5-year grant include: 1) Developing the largest family-based repository of children with primary ADHD and their family members using...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants supports a research project focused on understanding the neural basis of dopamine-driven deficits in cognition and perception. The $774,632 award, effective April 1, 2025 through March 31, 2030, will be conducted by Northwestern University. The project aims to use in vivo imaging and genetic approaches to investigate how excess dopamine signaling in the dorsal...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $370,970 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to study ATP1A3-related disorders in Brazil. The key objectives are to: 1) characterize the genotype-phenotype correlation and natural history of these rare neurological...
This $254,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to characterize a specialized serotonergic-septohippocampal brain circuit and its role in modulating context-triggered drug-seeking behavior and relapse vulnerability. The research will be conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, from July 2024 through June 2026. Specifically, the grant...