Project Grant K08NS144598
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
- This federal Project Grant award of $501,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to determine the mechanisms of dopamine transmission in the brain and how it regulates motor function and learning. The research aims to understand how different dopamine signals mediate transmission and impact aspects of motor activity and learning,...
- This Project Grant award of $422,125 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the fundamental roles of the DNAJC12 protein in dopamine production and brain function. The research aims to specifically ablate DNAJC12 in dopaminergic neurons in order to ascertain the effects of this gene dysfunction on dopamine synthesis,...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $2,723,954.00 to the University of Alabama at Birmingham (UAB) from June 1, 2025 to May 31, 2027. The grant supports research focused on understanding the effects of 14-3-3θ protein phosphorylation on vesicular transport and alpha-synuclein aggregation, which are key mechanisms...
- This federal Project Grant award of $164,516 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports a research project at New York University School of Medicine to investigate the neural mechanisms underlying speech planning and its relationship to speech disorders in Parkinson's disease patients. Specifically, the project aims to study...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel gene therapy approach to reduce neurotoxicity in Parkinson's disease. The $1,009,212 award to the Van Andel Research Institute in Grand Rapids, MI will fund pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to enhance the activity of the...
- This federal Project Grant award of $476,643.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports research to study the neurophysiological basis of impaired gait in mouse models of Parkinson's disease. The key objectives are to examine how the dorsolateral striatum and substantia nigra pars reticulata, which are part of the basal ganglia, encode gait...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 3-year, $113,268 Project Grant to Texas A&M University System Health Science Center to conduct research on the role of endoplasmic reticulum-exit site upregulation in neuroprotection against Parkinson's disease. This project, funded under NINDS's Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to investigate whether increases in SEC24D-containing endoplasmic...
- This federal Project Grant award for $155,000.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to characterize a mouse model with a rare variant of the AIMP2 gene, which has been linked to late-onset Parkinson's disease (PD). The research aims to create an R65C AIMP2 knock-in mouse model using CRISPR technology and...
This federal Project Grant award of $220,260.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of the grant is to investigate the role of the RNA-binding protein ELAVL3 in regulating glutamate and dopamine receptor signaling in the striatal neurons of the brain, with the goal of understanding the molecular mechanisms underlying striatal dysfunction in Parkinson's disease. The project, titled "RNA Regulation in Medium Spiny Neurons of the Striatum in Parkinson's Disease", is being conducted by researchers at Rockefeller University and has a performance period from August 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $220.3k | 7/30/25 |