This Project Grant award of $628,133 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, supports research to understand the metabolic mechanisms underlying recovery from mild traumatic brain injury (TBI). The primary award to Rutgers, The State University, will investigate how the activation of the enzyme CYPIN can help regulate methionine levels and...
The National Institutes of Health's National Institute on Aging awarded a $2,366,184 Project Grant to The General Hospital Corporation, doing business as Massachusetts General Hospital, to support research into the mechanisms of circadian and synaptic dysfunction after repetitive mild traumatic brain injury. The three-year award, made on June 1, 2022 under the Aging Research program (CFDA 93.866), will fund work by Drs. Whalen and Lipton to define how interleukin-1 receptor 1-mediated...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,537,727 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Trustees of the University of Pennsylvania. This 8-year research program, commencing June 1, 2024, aims to investigate the regulation and function of sleep across early development. Key objectives include: Defining the cellular and circuit properties of sleep/wake regulatory neurons throughout...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate using sharp wave-ripple stimulation as a potential strategy to enhance memory function in individuals who have sustained a traumatic brain injury (TBI). The total award amount is $195,000.00 over the period of June 15, 2024 to May 31, 2026. The research will...
This federal Project Grant award of $405,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at the University of Cincinnati to investigate the impacts of traumatic brain injury (TBI) on serotonin (5-HT) neuron function and its role in the development of neuropsychiatric disorders. The key objectives are to characterize TBI-induced alterations...
This R01 project grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $404,100 in funding to The General Hospital Corporation (doing business as Massachusetts General Hospital) to investigate the mechanisms of chronic blood-brain barrier dysfunction following traumatic brain injury (TBI). The research aims to identify an endothelial...
This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, will support a comprehensive scientific investigation into the role of epigenetic aging and its impact on patient outcomes after severe traumatic brain injury (TBI). The $2,248,793 award to the University of Pittsburgh will fund a 5-year research project to: Examine the link between accelerated epigenetic aging, measured through DNA methylation and epigenetic clock computations,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, will provide $615,627.00 in funding to the University of Pittsburgh to conduct research on the role of DNA methylation (DNAm) in pediatric traumatic brain injury (TBI) and neurobehavioral recovery. The research aims to comprehensively examine DNAm associated with the brain-derived neurotrophic factor (BDNF) gene, as well as conduct an unbiased...