Project Grant R01AG082734
Award Date
8/15/24
Completion Date
4/30/29
Dollars Obligated
$3.8M
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This federal Project Grant award, valued at $3,102,638.00 and spanning August 15, 2024 to July 31, 2027, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania. The grant aims to develop novel gyrencephalic animal models that can recapitulate the complex neuropathological and clinical features associated with traumatic brain injury (TBI)-induced Alzheimer's disease and related dementias (ADRD). The project will evaluate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $192,737 to Texas Tech University Health Sciences Center (TTUHSC) to investigate the mechanisms of traumatic brain injury (TBI)-induced accumulation of chondroitin-sulfate glycosaminoglycans (CS-GAGs) and their relationship to vascular and neuronal dysfunction. The research aims to determine if inhibition of prostaglandin-UCHL1 interactions can mitigate TBI-induced blood-brain barrier...
This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...
This Project Grant award of $794,978.00 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support a longitudinal study to examine accelerated epigenetic aging as a mechanism linking socioeconomic disadvantage across the lifespan to cognitive decline in midlife. The research will leverage the Adult Health and Behavior Project's existing data on individual socioeconomic status, neuropsychological assessments, and stored blood samples to analyze...
This $158,247 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the cell-specific neurodegenerative potential of mitochondria following traumatic brain injury (TBI). The project aims to study how TBI-induced disruptions in mitochondrial function contribute to the development of Alzheimer's-like neurodegeneration over time. Key objectives include determining injury-induced intracellular and extracellular alterations in...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the use of the adipokine adiponectin as a potential therapy to promote functional recovery after traumatic brain injury (TBI). The $571,404 award to the University of Pittsburgh will test the hypothesis that adiponectin receptor activation can mitigate...
This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $102,948.00 to Case Western Reserve University to investigate the link between traumatic brain injury (TBI), hematopoietic stem cell dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The key objectives are to assess how acute TBI induces changes to...
The National Institute on Aging (NIA) awarded a $4,269,339 Project Grant (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, for the project "Consequences of Exposure to Repetitive Head Impacts Across the Lifespan." The 2-year award, effective June 1, 2025, supports research to investigate the long-term clinical and neuropathological outcomes of repetitive head impact (RHI) exposure, including the development of...