This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the use of the adipokine adiponectin as a potential therapy to promote functional recovery after traumatic brain injury (TBI). The $571,404 award to the University of Pittsburgh will test the hypothesis that adiponectin receptor activation can mitigate...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,624 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Rutgers, The State University to conduct research on sleep and circadian rhythm disorders following traumatic brain injury (TBI). The project aims to use the Drosophila melanogaster genetic model to 1) identify genes that contribute to TBI-induced changes in sleep and circadian rhythms, and...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the potential impact of a low-fat, high-fiber diet in limiting traumatic brain injury (TBI)-induced neurodegenerative and inflammatory changes in a mouse model. The $498,713.00 award, with a performance period from July 2024 to June 2027, will support research to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on elucidating the role of metabolic regulation and AMPK activation in modulating neutrophil extracellular traps (NETs) formation and inflammation following traumatic brain injury (TBI). The $453,860 award, with a period of performance from June 1, 2025 to April 30, 2030, will...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" provides $404,100.00 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to study the mechanisms of chronic blood-brain barrier dysfunction after traumatic brain injury (TBI). The research aims to identify a signaling pathway involving the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $587,521.00 to the Regents of the University of Michigan to conduct research on mitigating secondary brain injury following traumatic brain injury (TBI). The key objectives of the research are to: (1) explore the molecular mechanisms of neurotrauma and the therapeutic...
This $158,247 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the cell-specific neurodegenerative potential of mitochondria following traumatic brain injury (TBI). The project aims to study how TBI-induced disruptions in mitochondrial function contribute to the development of Alzheimer's-like neurodegeneration over time. Key objectives include determining injury-induced intracellular and extracellular alterations in...
The University of Pittsburgh is receiving a $437,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant aims to provide proof-of-concept evidence that retinoic acid (RA) can attenuate cholinergic deficits and white matter connectivity impairments after traumatic brain injury (TBI). The two-year project will: 1) determine if RA treatment...
This $6,214,900 Project Grant award from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) federal grant program supports research on the role of genetic risk factors and immune response on neurovascular unit (NVU) function in post-traumatic brain injury (TBI) cognitive impairment. The primary awardee, the Scintillon Institute, a non-profit biomedical research organization in San Diego, California, will conduct this advanced scientific investigation over...