This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, will support a comprehensive scientific investigation into the role of epigenetic aging and its impact on patient outcomes after severe traumatic brain injury (TBI). The $2,248,793 award to the University of Pittsburgh will fund a 5-year research project to: Examine the link between accelerated epigenetic aging, measured through DNA methylation and epigenetic clock computations,...
This Project Grant award of $628,133 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, supports research to understand the metabolic mechanisms underlying recovery from mild traumatic brain injury (TBI). The primary award to Rutgers, The State University, will investigate how the activation of the enzyme CYPIN can help regulate methionine levels and...
The University of Pittsburgh is receiving a $437,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant aims to provide proof-of-concept evidence that retinoic acid (RA) can attenuate cholinergic deficits and white matter connectivity impairments after traumatic brain injury (TBI). The two-year project will: 1) determine if RA treatment...
This $2,888,616 cooperative agreement award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support analytical validation of 7 emerging biomarkers for traumatic brain injury (TBI). The University of Pittsburgh, as the prime recipient, will partner with Morehouse School of Medicine, The Hospital for Sick Children, and the University of British Columbia as sub-awardees...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop and assess novel frameworks that can accurately predict functional outcomes at 6 months post-injury for patients with moderate-to-severe traumatic brain injury (TBI). The $389,813 award, with a period of performance from August 5, 2024 to July 31, 2026, will...
This federal Project Grant award for $102,948.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research on the relationship between traumatic brain injury (TBI), hematopoietic stem cell (HSC) dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The key objectives are to investigate how acute TBI induces changes to HSCs that...
This federal Project Grant award of $405,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at the University of Cincinnati to investigate the impacts of traumatic brain injury (TBI) on serotonin (5-HT) neuron function and its role in the development of neuropsychiatric disorders. The key objectives are to characterize TBI-induced alterations...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of thalamic microglia in driving cognitive impairment after cortical injuries, with a focus on traumatic brain injury (TBI). The $556,661 award, effective from June 18, 2024 to May 31, 2029, will enable researchers at the University of Alabama at Birmingham...
This $465,752 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research at the University of Michigan-Dearborn to evaluate changes in cell chirality and cell-cell interactions within the neurovascular unit following traumatic brain injury (TBI). The key objectives are to determine the impacts of TBI on the chirality,...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,855 to Mito-Biotherapeutics, Inc. aims to develop a novel fusion protein construct (NFP) that can cross the blood-brain barrier and deliver a therapeutic payload to repair mitochondrial DNA damage in neurons following traumatic brain injury (TBI). The proposed research program will verify the NFP's technical capability for complex navigation, and demonstrate its ability to...