Project Grant R21NS131962
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded a $449,391 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Florida to study combinatorial respiratory rehabilitation approaches to enhance breathing recovery after cervical spinal cord injury. The project aims to maximize breathing recovery in patients with chronic, incomplete...
- This federal Project Grant award for $569,695.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research into the therapeutic potential of phrenic proprioceptors, or sensory neurons, to restore respiratory function after cervical spinal cord injury. The research, conducted by Marquette University, aims to test the hypothesis that activating these phrenic proprioceptors can induce spinal plasticity and improve breathing...
- This Project Grant award of $305,447, issued on September 2, 2024 by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to identify predictive biomarkers for acute intermittent hypoxia-induced motor recovery in individuals with incomplete spinal cord injury. The research team from the University of Colorado will: 1) Validate the cellular mechanisms underlying hypoxia-induced plasticity in humans, using...
- This $146,703 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the cellular and molecular mechanisms underlying respiratory control dysfunction in hypertension. The principal investigator will use electrophysiology and imaging approaches to study the role of the retrotrapezoid nucleus (RTN) in regulating the respiratory response to changes in CO2/H+ in spontaneously hypertensive rats. The...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $411,941 to Drexel University to conduct research on identifying novel trunk reflex pathways and how they differ after neonatal versus adult spinal cord injury in animal models. The key objectives are to test the hypothesis that the newly discovered contralateral monosynaptic trunk...
- The University of Florida was awarded a $130,053 Project Grant from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on the use of closed-loop epidural stimulation to improve breathing function in individuals with spinal cord injuries. The research aims to understand the functional and neuroplastic effects of epidural stimulation, as well as the neural populations responsible for its action, with the goal of...
- This $673,512 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing rhythms. The project aims to determine whether the subconscious breathing rhythm arises from an autonomous oscillator or reciprocal inhibition between key neuronal populations in the brainstem. UCSF will use advanced mouse...
- This Project Grant award of $497,628.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into pulmonary vagal sensory neurons and their role in breathing abnormalities associated with bronchopulmonary dysplasia (BPD) in preterm infants. The research aims to elucidate the dose- and duration-dependent effects of neonatal hyperoxia exposure on breathing control and the functional roles of distinct populations of...
- The University of Florida received a $149,348 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the cellular mechanisms of acute-intermittent hypercapnic-hypoxia induced phrenic motor plasticity. The project will monitor phrenic nerve activity in anesthetized rats as a proxy for respiratory motor output, with the goal of enhancing understanding of the pathways involved in phrenic long-term facilitation (PLTF)...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to Dr. Nicholas Burgraff to conduct research aimed at understanding the neurophysiological mechanisms by which opioids disrupt respiratory function and lead to airway constriction. The research seeks to identify new therapeutic approaches to mitigate the life-threatening respiratory complications of opioid overdose. The award will...
RESPIRATORY MOTOR CONTROL IN THE INTACT AND INJURED SPINAL CORD - RESPIRATORY DEFICITS ARE A COMMON CONSEQUENCE OF CERVICAL SPINAL CORD INJURY (SCI). THIS IS PRIMARILY DUE TO DAMAGE TO THE NEURAL PATHWAYS CONTROLLING THE RESPIRATORY MUSCLES, INCLUDING DIAPHRAGM - THE PRIMARY MUSCLE OF RESPIRATION. RESPIRATORY ACTIVITY CAN SPONTANEOUSLY IMPROVE AFTER SCI, HOWEVER, THE EXTENT OF RECOVERY IS LIMITED AND SEVERE RESPIRATORY DEFICITS PERSIST. DESPITE CONSIDERABLE RESEARCH EFFORTS, THE MECHANISMS OF RESPIRATORY RECOVERY POST-SCI REMAIN UNKNOWN. HERE, WE WILL USE THE CONCEPT OF THE MODULAR ORGANIZATION OF MOTOR CONTROL TO STUDY THE INTACT RESPIRATORY SYSTEM AND ITS DEFICITS AND RECOVERY IN CERVICAL SCI RATS. THE MODULAR ORGANIZATION OF MOTOR CONTROL WAS PROPOSED SEVERAL DECADES AGO AND HAD BEEN MAINLY DEVELOPED WITH A FOCUS ON THE LOCOMOTOR SYSTEM. IN THIS WORK, FOR THE FIRST TIME, WE WILL STUDY THE MODULAR ORGANIZATION OF RESPIRATORY CONTROL AND ITS CHANGES AFTER CERVICAL SCI IN FREELY BEHAVING RATS. A C2 SPINAL CORD SEGMENT HEMISECTION (C2HX) WILL BE EMPLOYED AS A MODEL OF SCI. ELECTROMYOGRAMS (EMG) FROM MULTIPLE RESPIRATORY MUSCLES WILL BE RECORDED, AND INDEPENDENT COMPONENT ANALYSIS (ICA) WILL BE USED TO IDENTIFY A SET OF MODULES RESPONSIBLE FOR CONTROLLING DIFFERENT RESPIRATORY BEHAVIORS. ICA WILL EXTRACT RESPIRATORY MODULES PRESENTED BY NEURAL PATTERNS (DRIVE PRIMITIVES) THAT ACTIVATE GROUPS OF RESPIRATORY MUSCLES WITH DIFFERENT WEIGHTS, CALLED SYNERGIES. BREATHING IS VERY HETEROGENEOUS AND CAN BE DIVIDED INTO MANY TYPES, INCLUDING RESTING AND ACTIVE BREATHING, CHALLENGED BREATHING, AND BREATHING DURING DIFFERENT STAGES OF SLEEP. WE HYPOTHESIZE THAT DIFFERENT TYPES OF BREATHING ARE ORGANIZED BY COMBINING DIFFERENT MODULES. THEREFORE, THE GOALS OF THE PROPOSED WORK ARE TO 1) IDENTIFY THOSE BASIC RESPIRATORY MODULES AND THEIR ARRANGEMENTS TO PRODUCE VARIOUS RESPIRATORY BEHAVIORS IN INTACT RATS; 2) EVALUATE MODULAR CHANGES AFTER CERVICAL SCI; 3) CORRELATE REMAINING MODULES IMMEDIATELY AFTER SCI WITH THE EXTENT OF SPONTANEOUS RECOVERY AND LASTING RESPIRATORY DEFICITS. OVERALL, THIS HIGHLY INNOVATIVE STUDY WILL INCREASE OUR BASIC KNOWLEDGE ABOUT THE ORGANIZATION OF A HEALTHY RESPIRATORY SYSTEM DURING DIFFERENT BEHAVIORS, ITS DEFICITS, AND RECOVERY AFTER CERVICAL SCI AND HELP DEVELOP ELECTROPHYSIOLOGICAL BIOMARKERS TO PREDICT THE EXTENT OF RESPIRATORY RECOVERY POST-INJURY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/22/25 | ||
| Not listed | $405.6k | 9/11/23 |