Project Grant R01HL179101
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $586,021 to The Medical College of Wisconsin, Inc. to establish patient-reported outcome measures that refine neonatal risk stratification and identify barriers to post-discharge specialty care for preterm infants with bronchopulmonary dysplasia (BPD). The goal is to identify hospital-to-home transition strategies that reduce post-prematurity respiratory...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $106,391 to the University of Colorado-Denver to investigate the role of developmental dysanapsis in lung development over the lifespan in an experimental bronchopulmonary dysplasia (BPD) model. The research aims to determine whether intra-amniotic endotoxin causes persistent dysanaptic growth of the airways, distal parenchyma, and vasculature in BPD, and...
- This $721,826 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify molecular mechanisms regulating alveolar matrix fibroblast function and their role in supporting vascular capillary formation. The research is being conducted by Children's Hospital Medical Center in Cincinnati, Ohio to advance the understanding of alveolar septation and septal wall maturation, which is...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $166,395 to Columbia University to conduct a 5-year research project on the impact of hyperoxia (excess oxygen) on the function of respiratory progenitor cells in neonates. The project aims to develop a better understanding of the mechanisms by which post-natal lung development occurs in the face of injurious agents like oxygen...
- This federal Project Grant award for $569,695.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research into the therapeutic potential of phrenic proprioceptors, or sensory neurons, to restore respiratory function after cervical spinal cord injury. The research, conducted by Marquette University, aims to test the hypothesis that activating these phrenic proprioceptors can induce spinal plasticity and improve breathing...
- This $673,512 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing rhythms. The project aims to determine whether the subconscious breathing rhythm arises from an autonomous oscillator or reciprocal inhibition between key neuronal populations in the brainstem. UCSF will use advanced mouse...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $773,868 to Baylor College of Medicine to elucidate the mechanisms regulating inflammation and the role of regulatory T cells (Tregs) in the development of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH). The award aims to use well-established murine models and human biosamples to examine the mechanistic and therapeutic potential of Tregs in...
- This federal Project Grant award, valued at $744,305 and awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports a research project titled "Molecular Physiology of PHOX2B-Expressing RTN Chemoreceptor Neurons" at the University of Virginia. The research examines gene regulatory functions of the PHOX2B transcription factor and its relevance for the function and connectivity of retrotrapezoid nucleus...
- This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the role of the hedgehog pathway and primary cilia axis in human lung alveologenesis and diseases such as bronchopulmonary dysplasia (BPD). The $156,168 grant awarded to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center will fund a 2-year study examining the cellular and molecular...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) totaling $1,480,392 will fund research at Case Western Reserve University (CWRU) to investigate the potential adverse effects of neonatal continuous positive airway pressure (CPAP) on lung development. The research aims to identify mechanisms by which CPAP exposure during the neonatal period can contribute to airway hyperreactivity, wheezing, and other respiratory issues...
This Project Grant award of $497,628.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into pulmonary vagal sensory neurons and their role in breathing abnormalities associated with bronchopulmonary dysplasia (BPD) in preterm infants. The research aims to elucidate the dose- and duration-dependent effects of neonatal hyperoxia exposure on breathing control and the functional roles of distinct populations of pulmonary vagal sensory neurons. This work will employ a novel mouse model and leverage advanced techniques like chemogenetics to better understand the underlying neural mechanisms contributing to compromised breathing in infants with BPD, a common respiratory complication of preterm birth. The project will be conducted by The Medical College of Wisconsin, Inc., a prominent medical research institution, and is scheduled for completion by May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $497.6k | 8/6/25 |