This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $249,000 to the University of Wisconsin-Madison to conduct research on the neurophysiological mechanisms underlying opioid-induced airway constriction. The primary objective is to better understand how opioids, particularly fentanyl, disrupt the autonomic regulation of airway function, with the goal of developing novel therapeutic strategies to complement or replace conventional opioid overdose reversal treatments. The research will leverage advanced techniques such as retrograde viral tracing, optogenetics, and high-density neural recordings to investigate the specific neural circuits and pathways involved in opioid-induced airway constriction. This project, which runs from May 2025 to April 2028, aims to expand the recipient's expertise in translational physiology, respiration, and rhythm generation, and ultimately contribute to improving patient safety and outcomes in medical scenarios where opioids are used.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $249.0k | 5/16/25 |