Project Grant R01NS142310

Award Date 6/1/25
Completion Date 4/30/30
Dollars Obligated $449K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Florida, USA
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This Project Grant award of $449,391.00, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop combinatorial respiratory rehabilitation approaches to enhance breathing recovery after cervical spinal cord injury (SCI).

The key products or services to be delivered through this 5-year grant include: 1) Studying the effects of pairing therapeutic acute intermittent hypoxia (TAIH) with two distinct respiratory training paradigms - treadmill exercise and exposure to elevated carbon dioxide (hypercapnia) - to maximize breathing recovery in chronic, incomplete cervical SCI; 2) Testing the cellular mechanisms underlying the synergistic effects of TAIH and task-specific respiratory training, focusing on spinal BDNF/TrkB signaling in phrenic motor neurons; and 3) Analyzing lasting changes in the neural circuits innervating phrenic motor neurons to increase their excitability and motor output. This research aims to inform future clinical trials and accelerate the translation of promising ideas into clinical practice for restoring independent breathing ability after chronic SCI.

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