Project Grant R01HL179209
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded a $449,391 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Florida to study combinatorial respiratory rehabilitation approaches to enhance breathing recovery after cervical spinal cord injury. The project aims to maximize breathing recovery in patients with chronic, incomplete...
- This $437,621 Project Grant was awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to Marquette University in Milwaukee, WI. The grant supports research to develop a combined therapeutic approach using acute intermittent hypoxia and respiratory-triggered diaphragm pacing to restore breathing function in individuals with chronic cervical spinal cord injury. The award has a performance period from September 30, 2025 to September 29, 2028....
- The University of Florida received a $149,348 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the cellular mechanisms of acute-intermittent hypercapnic-hypoxia induced phrenic motor plasticity. The project will monitor phrenic nerve activity in anesthetized rats as a proxy for respiratory motor output, with the goal of enhancing understanding of the pathways involved in phrenic long-term facilitation (PLTF)...
- This Project Grant award of $497,628.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into pulmonary vagal sensory neurons and their role in breathing abnormalities associated with bronchopulmonary dysplasia (BPD) in preterm infants. The research aims to elucidate the dose- and duration-dependent effects of neonatal hyperoxia exposure on breathing control and the functional roles of distinct populations of...
- This $673,512 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing rhythms. The project aims to determine whether the subconscious breathing rhythm arises from an autonomous oscillator or reciprocal inhibition between key neuronal populations in the brainstem. UCSF will use advanced mouse...
- This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a study to investigate the impact of selective vagal neuromodulation on heart failure indices. The 2-year project, with a start date of September 1, 2025, will be conducted by the University of Colorado-Denver. The research aims to better understand the neural interface by studying the effects of selective activation of cholinergic (efferent)...
- This federal Project Grant award, valued at $518,613.00 and granted by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to define the molecular basis of thrombospondin-1-induced fibro-fatty diaphragm remodeling, a driver of obesity-associated respiratory dysfunction. The research, conducted by the Regents of the University of Michigan, aims to investigate the role of the matricellular protein thrombospondin-1 in promoting...
- The University of Florida was awarded a $130,053 Project Grant from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on the use of closed-loop epidural stimulation to improve breathing function in individuals with spinal cord injuries. The research aims to understand the functional and neuroplastic effects of epidural stimulation, as well as the neural populations responsible for its action, with the goal of...
- This $146,703 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the cellular and molecular mechanisms underlying respiratory control dysfunction in hypertension. The principal investigator will use electrophysiology and imaging approaches to study the role of the retrotrapezoid nucleus (RTN) in regulating the respiratory response to changes in CO2/H+ in spontaneously hypertensive rats. The...
- The National Science Foundation (NSF) awarded a $274,841 Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant to XN Health Inc. on July 15, 2025 to develop a novel transtracheal phrenic nerve stimulation device. This device aims to reduce lung and diaphragm injuries caused by mechanical ventilation, which affects an estimated 1.2 million Americans annually. The project will optimize stimulation parameters, develop an automated algorithm, and validate the system for chronic use in...
This federal Project Grant award for $569,695.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research into the therapeutic potential of phrenic proprioceptors, or sensory neurons, to restore respiratory function after cervical spinal cord injury. The research, conducted by Marquette University, aims to test the hypothesis that activating these phrenic proprioceptors can induce spinal plasticity and improve breathing recovery. Key objectives include examining how phrenic proprioceptor activation induces distinct forms of phrenic motor plasticity and how this mechanism is altered after spinal cord injury. This award, with an ultimate completion date of May 31, 2030, builds on the institution's prior work demonstrating that diaphragm pacing can promote ventilator weaning and independent breathing in some individuals with cervical spinal cord injury.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $569.7k | 8/18/25 |