Project Grant R21MH142338
- The National Institute of Mental Health (NIMH) awarded a $3,613,504 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Icahn School of Medicine at Mount Sinai (ISMMS) on September 22, 2025. This 4-year grant aims to investigate the role of the NLRP3 inflammasome in HIV-induced neuroinflammation and its impact on HIV persistence in the central nervous system (CNS). The project has three key objectives: 1) Elucidate the link between HIV-1 infection and NLRP3...
- This federal Project Grant award from the National Institutes of Health National Institute of Mental Health provides $6,499,884 to Yale University under the Mental Health Research Grants program (CFDA 93.242) to study the longitudinal nervous system consequences of SARS-CoV-2 in people with HIV-1 treated in early infection. The award will fund research from September 2022 to September 2025 to analyze pre- and post-COVID-19 data from a cohort of early antiretroviral therapy-treated people with...
- The National Institute of Mental Health (NIMH) awarded a $678,674 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Rush University Medical Center. The grant aims to identify the molecular mechanisms that trigger the activation of intracellular innate immunity in microglia and characterize the cellular crosstalk between HIV-infected and non-infected cells in the brain under physiological concentrations of combination antiretroviral therapy (cART). The research...
- This federal Project Grant award of $194,375.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to determine the impact of persistent HIV in the central nervous system (CNS) on inflammation, brain structure and function, and cognition in people living with HIV. The primary goals are to: 1) Evaluate the specific contribution of HIV in the CNS to...
- The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation. The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal...
- The National Institute of Mental Health (NIMH) awarded a $733,355 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Alabama at Birmingham (UAB) to evaluate social brain health in people living with HIV. The project, titled "Evaluating Social Brain Health in HIV: An RDoC-Based Approach," will investigate the complex set of social cognitive abilities, including recognizing social cues and inferring others' mental states, which are crucial...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,025,015 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Scintillon Institute in California. The grant, awarded on August 11, 2025, supports the development of a next-generation preclinical model of NeuroHIV that better recapitulates the neuro-immune-vascular system interactions in the context of antiretroviral therapy-mediated HIV suppression....
- This $823,691 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the role of immune checkpoints in the central nervous system (CNS) of people living with HIV (PLWH) and their association with HIV-associated neurocognitive disorder (HAND). The research aims to determine the profiles and biological functions of soluble immune checkpoints (sICPs) in the CNS of PLWH and a simian immunodeficiency...
- The University of Texas Southwestern Medical Center was awarded a $837,097 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports a study to investigate the relationship between cognitive impairment and microglial proliferation in people with virally-suppressed HIV (VS+PWH). The research aims to use positron emission tomography (PET) imaging of the translocator protein 18 kDa (TSPO) and the colony...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $881,439 in funding to the University of North Carolina at Chapel Hill to conduct research on the evolution and latency of HIV in people infected with the subtype C virus. The key objectives of the project are to: determine the frequency of macrophage-tropic virus evolution in the central nervous system (CNS); identify which cell types in the CNS...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the role of cerebrospinal fluid (CSF) memory B cells in HIV-associated neuroinflammation and cognitive impairment. The $491,700 award to Yale University will fund a 2-year study to generate monoclonal antibodies from CSF-derived memory B cells in people with HIV on antiretroviral therapy, and screen them for reactivity against HIV, opportunistic pathogens, and autoantigens. This research aims to elucidate the unique and potentially pathogenic role of CNS-resident memory B cells in driving persistent neuroinflammation and neuronal injury, despite viral suppression. The findings could uncover novel mechanisms and targets for addressing cognitive impairment in people living with HIV.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $491.7k | 9/3/25 |