Project Grant R21MH138991
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a $1,504,616 Project Grant on June 12, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the relationship between N-acetyl-aspartyl-glutamate (NAAG) and memory deficits in schizophrenia patients in mid- to late-life. The research addresses a critical gap in understanding cognitive dysfunction, which is a core feature of schizophrenia that...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Scripps Research Institute $878,601 under the Mental Health Research Grants program (CFDA 93.242) for a Project Grant commencing April 1, 2026, and concluding December 31, 2030. This collaborative research initiative aims to advance understanding of neural circuit reorganization underlying memory formation through structural and computational analysis. The project delivers detailed neuronal connectome...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $197,640 under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025 through August 31, 2030. This award supports an early-career investigator's research into the functional consequences of schizophrenia-associated genetic variants in GRIA3, a gene encoding the GluA3 subunit of the AMPA receptor...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $745,840 under the Mental Health Research Grants program (CFDA 93.242) to the Research Foundation For Mental Hygiene, Inc., Nathan S Kline Institute, effective May 1, 2026, through February 28, 2031. This Project Grant supports basic neuroscience research investigating optimal timing and cognitive conditions for memory consolidation during wakefulness. The research employs advanced functional magnetic resonance...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $104,349.00 under the Mental Health Research Grants program (CFDA 93.242) for the period April 1, 2026 through March 31, 2028. The project, titled "Attentional Modulation of Neural Activity in Multi-Attribute Decision Making," investigates how attention influences neural processing during complex decision-making involving multiple attributes. The research...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $443,931 under the Mental Health Research Grants program (CFDA 93.242) for the period July 1, 2025 through June 30, 2027. This research project aims to develop and validate novel methodologies for accurately tracking structural brain changes using low-field (0.05T) magnetic resonance imaging (MRI) technology coupled with autonomous control systems and...
- This Project Grant award of $150,104, issued by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) on March 1, 2026, supports basic neuroscience research investigating the role of myelin plasticity in long-term memory formation and recall. The research will be conducted at the University of California, San Francisco through October 31, 2028. The investigator will employ an active avoidance learning paradigm in mice to identify which...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a $1.1 million Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective May 1, 2026 through January 31, 2031. This research grant supports a five-year investigation into the effects of broadly neutralizing antibodies (BNAbs) on neuroinflammation and central nervous system (CNS) persistence in simian immunodeficiency virus (SIV)-infected antiretroviral...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Harvard College a $784,177 Project Grant (CFDA 93.242 – Mental Health Research Grants) effective May 1, 2026, through April 30, 2031, to investigate techniques for altering emotional responses associated with memories. The research leverages reactivation-induced memory change (RIMC) to examine factors that may reduce, enhance, or infuse negative feelings elicited by memories of emotional events. The project...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Trustees of Boston University a $449,625 Project Grant under the Mental Health Research Grants program (CFDA 93.242) on March 15, 2026, for a 24-month research period concluding March 14, 2028. The project investigates the molecular, cellular, and circuit-level mechanisms underlying working memory maintenance through an integrated research approach. The research delivers scientific knowledge and methodological...
Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant totaling $427,625 under the Mental Health Research Grants program (CFDA 93.242) on May 15, 2026, with a completion date of April 30, 2028. The award funds the development of "CHEMI-KNOCK," an innovative molecular tool utilizing chemical-based manipulation to achieve rapid and precise inactivation of target proteins in live animal brains during memory consolidation. This research tool is designed to relocate endogenous proteins from their active sites to other subcellular locations within minutes upon chemical triggering, enabling study of specific neuron types in the hippocampus of freely moving rats without genetic modification. The primary deliverable is the creation and validation of this chemical-based loss-of-function technique with minute temporal resolution. The research addresses a critical gap in understanding memory consolidation mechanisms by targeting plasticity-related proteins (PRPs) that stabilize synaptic plasticity. Using activity-regulated cytoskeleton associated protein (ARC) as a model target, the project aims to elucidate the molecular mechanisms underlying the transformation of short-term memories into long-term ones. Upon successful completion, this work is expected to generate novel mechanistic insights into memory consolidation, identify key PRPs involved in the process, and potentially reveal new pharmacological targets for therapeutic intervention—advancing fundamental neuroscience knowledge relevant to memory disorders and mental health conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 5/19/26 |