Project Grant K08MH138673
- This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), provides $804,690 to The Johns Hopkins University to determine the relationship between N-acetyl-aspartyl-glutamate (NAAG) levels and memory deficits in schizophrenia patients in mid- to late-life. The project aims to measure NAAG levels using magnetic resonance spectroscopy and correlate them with declarative and working memory performance in...
- This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to characterize a genetic mouse model for a gene implicated in neurodevelopmental disorders including autism, intellectual disability, and schizophrenia. The $742,484 award, with a project period from January 13, 2025 to October 31, 2029, will fund experiments to obtain multiome single nucleus RNA-sequencing,...
- This Project Grant award of $735,932 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate the cellular manifestations of positive symptoms, such as auditory hallucinations, in mouse models of two strong genetic predictors of schizophrenia - 22q11.2 microdeletion syndrome and 3q29 microdeletion syndrome. The research will focus on disruptions in thalamocortical projections between the auditory thalamus and auditory...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $706,404 to Thomas Jefferson University to conduct research on the pathophysiological roles of protein-protein interactions at excitatory synapses and their modifications in schizophrenia. The research aims to determine how defects in protein-protein interactions drive NMDA receptor hypofunction, a key aspect of the synaptic pathology in...
- This $137,060 Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) aims to develop the Platform for Analyzing Mutations Associated with Schizophrenia (PAMS). The key objectives of the project are to: Investigate the impact of missense mutations on protein stability for 12 schizophrenia risk genes using computational modeling and analysis. Predict the effects of mutations on protein-protein interactions by...
- This Project Grant award of $3,498,931.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to comprehensively investigate the impact of loss of 100 neurodevelopmental and psychiatric disorder (NPD) genes in mice. The project, titled "Cross Scale Interrogation of NPD Genes (SING) in Mice", will utilize knockout mouse models to examine gene expression, cellular changes, neural circuits, and behaviors across multiple...
- This $246,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at The University of Texas Southwestern Medical Center (UT Southwestern) to investigate age-dependent dysfunction in the dentate gyrus (DG) region of the hippocampus and its relationship to the pathophysiology of psychosis. The research aims to reverse-translate discoveries from post-mortem human brain analyses, specifically...
- This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of group III metabotropic glutamate receptors (mGlu4/7/8) in modulating glutamatergic signaling and their potential as targets for treating schizophrenia. The $217,818 award to Vanderbilt University, effective from September 9, 2025 to September 8, 2027, will fund studies to use pharmacological and...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the agency's Mental Health Research Grants program (CFDA 93.242), provides $162,486 to The Johns Hopkins University to study single neuron computations within brain-wide circuits. The research aims to characterize the spatiotemporal relationships between synaptic input patterns and action potentials, investigate how inputs change when the brain drives activity in specific neurons, and determine whether...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $714,615 to New York University School of Medicine to conduct research on dissecting the role of non-coding repeats in the genetics of psychiatric disorders like schizophrenia and bipolar disorder. The key objectives are to: Fine map regulatory features of a repeat expansion within the CACNA1C gene, which has been strongly associated with...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $197,640.00 to The Johns Hopkins University to investigate the functional consequences of schizophrenia-associated genetic variants in the GRIA3 gene, which encodes a key subunit of the AMPA receptor. The goal is to better understand the pathological mechanisms underlying schizophrenia, with the ultimate aim of identifying new therapeutic targets. The project will involve training the Principal Investigator in basic neuroscience concepts and techniques to examine the effects of GRIA3 variants on AMPA receptor assembly, trafficking, and kinetics, both in vitro and through gene expression changes in GRIA3-knockout mice in vivo. The award period is from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $197.6k | 8/27/25 |