Project Grant R21MH134002
- This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of striatal astrocytes in modulating dopamine signals and their impact on behavioral state transitions. The $725,422 award to the Massachusetts Institute of Technology (MIT), with a project period from May 1, 2025 to February 28, 2030, will fund electrophysiological studies to examine how striatal...
- The National Institute of Mental Health (NIMH) awarded a $1,737,000 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Max Planck Florida Corp, doing business as Max Planck Florida Institute For Neuroscience. The 3-year project, starting September 1, 2024, aims to systematically investigate the synaptic energy logistics that enable the brain to process and store information. Specifically, the research will discover novel regulators that dictate the flexibility of...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $470,996 to Vanderbilt University to conduct research on the neural basis of human working memory. The study aims to isolate spiking activity and local field potentials in the prefrontal cortex and other brain regions of human patients with intracranial electrodes, as they perform working memory tasks. The research will investigate whether neuronal...
- The National Institute of Mental Health (NIMH) awarded a $464,750 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College, also known as Harvard University. The purpose of this 2-year project, titled "GUT MICROBIOME CONTRIBUTIONS TO HUMAN EPISODIC MEMORY AND THE ROLE OF EARLY LIFE STRESS," is to identify the relationship between human gut microbiome composition, episodic memory performance, and the impact of early life...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $625,108 to the University of California, Irvine (UCI) to investigate the functions of the lateral entorhinal cortex in associative memory formation. The research aims to identify the roles of serotonin inputs and neural circuit interactions in the lateral entorhinal cortex, with the goal of advancing the understanding of how the...
- The National Institute of Mental Health (NIMH) awarded a $223,176 project grant under the Mental Health Research Grants program (CFDA 93.242) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The goal of this 2.5-year project is to define how novel post-translational modifications on histones, specifically histone crotonylation, are regulated by neuronal activity and to test their role in learning and memory. The...
- The federal Project Grant award of $797,402 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is supporting research at Cornell University to investigate the neural dynamics underlying brain state-dependent memory functions. The research aims to simultaneously monitor memory reactivation and brain states/substates in naturally sleeping mice, with the goal of understanding how the brain continuously incorporates new memories while...
- This $409,750 project grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to characterize the role of ventral pallidal astrocytes in approach/avoidance conflict behaviors in mice. The 2-year project, running from April 1, 2025 to March 31, 2027, will utilize fiber photometry and chemogenetic manipulations to investigate how astrocytes in the ventral pallidum regulate synapses and influence approach/avoidance behaviors...
- This $632,776 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) aims to fundamentally advance the understanding of astrocyte physiology. The grant supports research at Baylor College of Medicine to use novel genetically encoded voltage indicators (GEVIs) to measure astrocyte membrane potential and local neural activity in the mouse visual...
- This $410,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to develop an evidence base for using intracranial EEG (iEEG) to investigate how noninvasive stimulation can modulate hippocampal network activity and affect memory. The research has three primary objectives: 1) investigating the selectivity of hippocampal indirectly targeted stimulation (HITS) on iEEG activity, 2) testing whether HITS impacts...
The National Institute of Mental Health (NIMH) awarded a $440,000 Project Grant (R21MH134002) to Baylor College of Medicine to study astrocyte ensembles and their role in memory formation. The 2-year grant, starting on August 1, 2023, aims to define the properties of astrocyte engrams - the physical substrate of memory that has been underexplored to date. The research will use specialized mouse models and viral tools developed by the investigators to label and manipulate astrocyte ensembles during learning events in the hippocampus. The project's specific objectives are to 1) characterize whether astrocyte ensembles exhibit engram-like properties, 2) determine if manipulating these astrocyte populations can encode memory storage and recall, and 3) elucidate the cellular and molecular features of astrocyte engram populations. This work under the NIMH's Mental Health Research Grants program (CFDA 93.242) seeks to expand the understanding of astrocyte functions in hippocampal memory circuits.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 7/20/23 |