This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate lateral entorhinal cortex (LEC) dysfunction in an Alzheimer's disease (AD) mouse model. The $540,191 award to the University of California, Irvine aims to: (1) determine cell types showing activity dysfunction in the LEC, (2) assess if LEC dopamine dysfunction causes associative memory impairment, and (3) examine if LEC 20-40Hz oscillation deficits underlie associative...
The National Institute of Mental Health (NIMH) awarded a $431,750 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Irvine (UC Irvine) to investigate the role of the medial striatum in spatial sequence learning and its interaction with the hippocampus. The two-year study, running from September 1, 2023 to August 31, 2025, aims to evaluate how the dorsomedial striatum contributes to the disambiguation of repeated spatial traversals that occur in...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) to Northwestern University totaling $553,788 for the period of January 1, 2025 to December 31, 2029. The purpose of this grant is to investigate the microcircuit mechanisms that underlie the distributed cortical contributions to working memory in mice. The researchers will use simultaneous two-photon calcium imaging and optogenetic stimulation techniques to compare how the...
The National Institute of Mental Health (NIMH) awarded a $665,893 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Regents of the University of Michigan to conduct research on "Consolidation and Interference of Hippocampal Spatial Maps." The research aims to utilize advanced machine learning techniques and large-scale population recordings to study how hippocampal activity during sleep supports the stabilization of memories of experiences in...
This $1,425,651 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to identify the neural mechanisms underlying interactions between distinct learning systems. The award to the University of Maryland, Baltimore funds a multi-year study to investigate how the prefrontal cortex coordinates learning across procedural and declarative memory systems. Key objectives include determining the task...
The University of California, Los Angeles (UCLA) received a $682,470 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award, effective August 15, 2024 through May 31, 2029, will support research to elucidate the regulation of cell fate specification in the development of the human cortex. This work aims to advance understanding of the underlying mechanisms that establish cortical arealization and...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 "Mental Health Research Grants" will support research on the mechanisms and functions of temporal coordination in the entorhinal-hippocampal network. The $571,694 grant to Cornell University will enable researchers to investigate how gamma-frequency synchronization between the hippocampus and entorhinal cortex supports spatial and non-spatial learning and memory formation in rats....
The National Institute of Mental Health (NIMH) awarded a $440,000 Project Grant (R21MH134002) to Baylor College of Medicine to study astrocyte ensembles and their role in memory formation. The 2-year grant, starting on August 1, 2023, aims to define the properties of astrocyte engrams - the physical substrate of memory that has been underexplored to date. The research will use specialized mouse models and viral tools developed by the investigators to label and manipulate astrocyte ensembles...
This federal Project Grant award from the National Institute of Mental Health (NIMH) provides $781,119 to the University of California, San Francisco (UCSF) to conduct research on "Dissecting the Circuits and Population Dynamics that Represent Unconditioned and Conditioned Stimuli in the Ventral Hippocampus". The project, awarded under CFDA 93.242 - Mental Health Research Grants, aims to understand how different classes of ventral CA1 neurons in the hippocampus acquire, update, and...
This $446,627 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research by the University of California, San Diego (UCSD) to investigate orientation tuning and directional encoding in the dorsal subiculum of the hippocampus. The project aims to systematically examine whether individual subicular neurons can encode multiple directions of travel, and how this encoding may be influenced by environmental...