Project Grant R21MH134157
Award Date
8/1/23
Completion Date
7/31/25
Dollars Obligated
$465K
Federal Agency
National Institute of Mental Health
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants provides $549,140 in funding to the University of Miami to conduct research on how bacterial quorum sensing molecules, specifically autoinducer-2 (AI-2), mediate the mammalian stress response. The key research objectives are to: 1) determine if stress regulates gut bacterial production of AI-2, 2) assess the contribution of bacterial AI-2 to...
This $120,015 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the neural mechanisms underlying homeostatic, physiological, and social behaviors. The awardee, President and Fellows of Harvard College, will develop a novel technological pipeline to monitor large-scale neural activity in freely moving animals and identify the transcriptomic identities of individual neurons. This...
The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation. The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal...
The National Institute of Mental Health (NIMH) awarded a $537,035 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The McLean Hospital Corporation in Belmont, MA to conduct a multilevel characterization of sensory cortical disinhibition in post-traumatic intrusions. The project aims to link lower levels of inhibitory neural activity and excitatory/inhibitory neurotransmitter imbalances to perturbations in resting-state neural network dynamics, and further connect these sensory...
This is a Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the project titled "EARLY LIFE STRESS AND DIFFERENTIAL EFFECTS ON THE MOLECULAR MATURATION OF SPECIFIC SUBTYPES OF BRAIN SEROTONIN NEURONS". The $466,125 grant was awarded on August 25, 2023 to President And Fellows Of Harvard College, acting through the Harvard Medical School Division, to investigate the impact of early life stress and...
The National Institute of Mental Health (NIMH) awarded a $440,000 Project Grant (R21MH134002) to Baylor College of Medicine to study astrocyte ensembles and their role in memory formation. The 2-year grant, starting on August 1, 2023, aims to define the properties of astrocyte engrams - the physical substrate of memory that has been underexplored to date. The research will use specialized mouse models and viral tools developed by the investigators to label and manipulate astrocyte ensembles...
This $825,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the Massachusetts General Hospital to investigate the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. The research will leverage data from the REGARDS and CARDIA longitudinal cohort studies to examine associations between gut microbiome metabolites, brain imaging markers, and the...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to investigate the role of the serotonergic system in altering social behavior following early life adversity. The $444,125 award to George Washington University will fund a 2-year study using electrophysiology, behavioral assays, and fiber photometry to examine how early life stress impacts the excitability of serotonergic neurons and...
This $1,425,651 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the neural mechanisms that coordinate learning across distinct cognitive systems. The primary awardee, the University of Maryland, Baltimore, will conduct a multi-year study using advanced behavioral training, electrophysiological recordings, and optogenetic manipulations to identify how the prefrontal cortex...
The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...