This Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) supports research to develop a somatic mutation-resolved lineage tracing system. The $126,830 award, with a project period from February 1, 2025 to January 31, 2027, will enable the grantee, The Children's Hospital Corporation (dba Boston Children's Hospital), to reconstruct single-cell genealogical trees and detect associated somatic mutations and epigenetic...
This federal Project Grant award, with ID R01HG013679, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172). The $743,524 award, granted on September 19, 2024, will fund the "Expansion Genomics for High-Resolution Single-Cell and Spatial Epigenomics" project at Harvard University's Office for Sponsored Programs division through June 2028. The project aims to develop a new "Expansion Genomics" platform...
The federal Project Grant award of $1,234,692 by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) supports the development of Precyse, a novel biomolecule desktop imaging system based on high-speed atomic force microscopy (HSAFM). Evizia Inc., the awardee, aims to provide an improved quality control solution for next-generation sequencing (NGS) library preparation compared to the current standard of gel electrophoresis. Precyse can...
The National Human Genome Research Institute (NHGRI) awarded a $650,625 Project Grant (CFDA 93.172 - Human Genome Research) to The Broad Institute, Inc. to develop a novel platform called Helicase-Assisted Continuous Evolution (HACE) for performing multiplexed locus-specific hypermutation within the mammalian genome. This platform will utilize a nick-directed helicase fused to a deaminase domain to enable continuous mutagenesis across large genomic regions. The HACE system will be directed to...
This $1,100,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to President and Fellows of Harvard College supports research to develop a deeper understanding of the biology and evolution of plasmids - small DNA molecules that can transfer traits like antibiotic resistance between bacteria. The research will create novel experimental tools and techniques to precisely measure intracellular plasmid competition, examine tradeoffs...
This federal Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $1,205,737.49 to The Regents of the University of California, Berkeley (UC Berkeley) to develop scalable computational methods and software tools for genomic data analysis and interpretation. The key products to be delivered include: Novel maximum likelihood estimation (MLE) frameworks and optimization techniques to dramatically accelerate...
This $299,993 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will pilot a participatory design accelerator model to cultivate ethical and equitable use of genetic technologies. The project, led by Harvard University's Office for Sponsored Programs, aims to facilitate cross-sector collaboration between genetics scientists, community leaders, policymakers, and other stakeholders. The goal is to generate insights and solutions to...
This $1,330,376 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences Biological Sciences program (CFDA 47.074) will fund the development of new computational methods for remote homology detection with evolutionary profile hidden Markov models. The grantee, President and Fellows of Harvard College, will implement divergence-parameterized statistical models of sequence evolution within the HMMER software package. This aims to improve the sensitivity...
The Massachusetts General Hospital will receive $3,024,000 through a three-year Project Grant from the National Institutes of Health Trans-NIH Research Support program to develop scalable methods for engineering and characterizing novel CRISPR-associated protein variants. The goal is to address limitations of current CRISPR-Cas enzymes by optimizing machine learning-guided directed evolution to create a catalog of customizable DNA editors with improved properties like expanded target...
This federal Project Grant award, provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), supports the development and commercialization of an innovative technology called CytopeDrop by Survey Genomics, Inc. CytopeDrop enables high-throughput, spatially-resolved single-cell multiomics analysis, allowing researchers to simultaneously profile mRNA abundance, protein abundance, and cell locations. The $1,887,931 award, effective from...