Project Grant R21HD123148
- The National Institute of Child Health and Human Development awarded The Regents of the University of Colorado $170,918 on September 27, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the relationship between embryonic glucose homeostasis and neural tube closure. The project runs through March 31, 2028, with performance in Boulder, Colorado. The research examines how insulin receptor substrate 1 (IRS-1) mediates embryonic glucose...
- The National Institute of Child Health and Human Development awarded The Regents Of The University Of Colorado, doing business as University Of Colorado-Denver, $114,268 in project grant funding on August 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research investigating how placental proteins influence prematurity outcomes. The project tests the hypothesis that proteins secreted by the preterm placenta—with documented...
- The National Institute of Child Health and Human Development awarded Baylor College of Medicine $149,190 on January 1, 2026, to conduct research on microRNA-290's role in regulating maternal-fetal nutrient exchange during neural tube closure under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research investigates how microRNA-290 expressed in extraembryonic tissues, including the yolk sac, affects nutrient transport to embryos during early pregnancy...
- The National Institute of Child Health and Human Development awarded The Regents of The University of Colorado (University of Colorado-Denver) $584,626 on July 8, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to define mechanisms regulating functional regionalization of the mammalian ovary during fetal and perinatal development. Using three-dimensional imaging, computational analyses, and single-cell-scale spatial transcriptomics, the research...
- The National Institute of Child Health and Human Development awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $669,594 on June 17, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate circulating extracellular vesicles as functional biomarkers of maternal mental and physical health in pregnancy and postpartum, with focus on women with high levels of adverse childhood experiences....
- The National Institute of Child Health and Human Development awarded The Regents of the University of Colorado (University of Colorado-Denver) $124,125 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of the Hedgehog signaling pathway—specifically GLI2—in endometrial remodeling and placental development. The project uses a mouse model with conditionally deleted uterine GLI2 to examine how the Hedgehog signaling...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded $429,000 in Project Grant funding to the University of Colorado-Denver for research conducted under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award was obligated on August 6, 2025, with a project completion date of July 31, 2027. This R21 mechanism grant supports research utilizing induced pluripotent stem cell (iPSC)...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded the University of Colorado-Denver a $2.26 million Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) on September 15, 2025, for research investigating inflammatory signaling mechanisms across the maternal-fetal interface. The research addresses critical gaps in understanding how inflammatory signals transfer through the placenta during...
- The National Institute of Child Health and Human Development awarded the University of Washington $128,169 under the Child Health and Human Development Extramural Research program (CFDA 93.865) on September 1, 2026, to conduct multi-omic dissection of early embryogenesis and neural tube defects using human gastruloids. The project integrates transcriptomics and proteomics to systematically profile gastruloid development, map protein interactomes, and model neural tube defects....
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded $429,000 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Program Grant R21NS151067). The award funds research on transcriptional and epigenetic regulation of neural progenitor fates during...
The National Institute of Child Health and Human Development awarded The Regents of the University of Colorado $430,375 on August 27, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate lipid droplet regulation and function in the developing neural tube. The research addresses how embryonic neural tubes utilize lipids to control development and how maternal metabolic disorders—type 2 diabetes and obesity—increase the risk of neural tube defects including anencephaly and spina bifida. The project examines lipid droplet dynamics during neural tube closure, an understudied morphogenetic process, and investigates how lipid abnormalities in maternal metabolic disorders contribute to structural birth defects. The work encompasses lipid uptake, synthesis, storage in lipid droplets, and lipid droplet breakdown to understand critical cellular processes during embryonic development. The award is a Project Grant with a period of performance extending through July 31, 2028. Place of performance is Boulder, Colorado. The Regents of the University of Colorado, operating through its Office of Contracts and Grants Division, is the recipient.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.4k | 8/28/26 |