Project Grant K99HD120632
- The National Institute of Child Health and Human Development awarded the University of Washington $698,290 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct functional tests of non-coding DNA variants associated with orofacial cleft risk. The research addresses the poor understanding of pathogenic mechanisms underlying orofacial cleft, a common structural birth defect with environmental and genetic contributions. Genome-wide...
- The National Institute of Child Health and Human Development awarded the University of Washington $564,830 on June 15, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to investigate sex differences in allelic gene regulation in human placenta. The research examines how sex chromosome dosage influences allelic gene regulation during placental development and trophoblast differentiation. The project determines whether sex chromosome...
- Federal Grant Award Summary The University of Washington received a $392,004 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 5, 2025, with a completion date of July 31, 2027. This award funds research on asymmetric RNA (ribonucleic acid) segregation in neural stem cells, specifically investigating how RNA molecules partition asymmetrically...
- The National Institute of Child Health and Human Development awarded the University of Washington $672,234 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, also designated 93.HDR). The project investigates metabolic regulation of immune cell function at the maternal-fetal interface. The research examines how nutrient availability and utilization impact immune cell phenotypes during pregnancy across all three trimesters. The work employs...
- The National Institute of Child Health and Human Development awarded The Medical College of Wisconsin, Inc., $639,854 on July 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate mechanically sensitive regulators of human amnion and primordial germ cell formation from a common progenitor. The research addresses infertility by examining the molecular basis of defective amnion formation and primordial germ cell (PGC) specification during...
- The National Institute of Child Health and Human Development awarded The Washington University $135,378 on August 26, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of maternal gut bacteria in fetal growth and placental development. The research defines bacterial metabolic pathways that influence fetal growth through immune cell function at the maternal-fetal interface, with specific focus on macrophages in placental villi and...
- The National Institute of Child Health and Human Development awarded the University of California, Santa Barbara $123,957 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) for research into how mechanical forces coordinate cell movements during vertebrate gastrulation, specifically examining the Spemann-Mangold organizer's role in establishing germ layers and embryonic axes. The funded research develops and applies...
- The National Institute of Child Health and Human Development awarded the University of Washington $406,020 on May 20, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop developmental age-specific neuroprotective therapies for perinatal brain injury, specifically addressing hypoxic-ischemic encephalopathy in late preterm infants (34–36 weeks' gestation). The research targets a gap between term infant HIE treated with therapeutic hypothermia and...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services, awarded Georgia TECH Research Corp $438,349 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop a computational model integrating microstructural growth dynamics with preclinical data to advance congenital diaphragmatic hernia (CDH) patch repair. The project addresses the high recurrence rate of CDH surgical repairs,...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
The National Institute of Child Health and Human Development awarded the University of Washington $128,169 under the Child Health and Human Development Extramural Research program (CFDA 93.865) on September 1, 2026, to conduct multi-omic dissection of early embryogenesis and neural tube defects using human gastruloids. The project integrates transcriptomics and proteomics to systematically profile gastruloid development, map protein interactomes, and model neural tube defects. Gastruloids—culturable stem cell models of gastrulation capable of developing cell types from all three germ layers—offer scalable platforms for studying congenital disorders, which account for a leading cause of infant mortality. Most prior gastruloid research has focused on genomics-based profiling; this award addresses the knowledge gap at the protein level to advance understanding of the cellular and molecular processes underlying gastrulation and congenital disorders. The work is performed at the University of Washington in Seattle, Washington, with a period of performance from September 1, 2026, through August 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.2k | 8/28/26 |