Project Grant R21HD120228
Award Date 8/14/26
Completion Date 7/31/28
Dollars Obligated $236K
Funding Federal Agency
Awarding Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44106, USA
Similar Awards
- The National Institute of Neurological Disorders and Stroke awarded the University of Florida $187,317 on July 20, 2026, to characterize the endometriosis microbiome and metabolomic pain phenotype under the Drug Use and Addiction Research Programs (CFDA 93.279). The project stratifies individuals with endometriosis into treatment-responsive groups by identifying differences in microbial and NAD+ metabolomic patterns associated with differing pain characteristics, quality of life, psychological...
- The National Institute of Child Health and Human Development awarded Trustees of Tufts College $351,945 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate inflammation resolution mechanisms in endometrial health and disease. The research dissects how specialized pro-resolving mediators, a class of lipid-derived molecules that orchestrate inflammation resolution, operate in the human endometrium across the menstrual cycle. The...
- The National Institute of Child Health and Human Development awarded Oregon State University $444,498 on August 18, 2026, to develop nanoparticle-mediated chemodynamic therapy for endometriosis under the Child Health and Human Development Extramural Research program (CFDA 93.865, Project Grant R01HD121601). Endometriosis affects approximately 176 million women worldwide, causing severe pelvic pain and infertility with no cure. Current clinical therapies cause infertility, and surgical lesion...
- The National Institute of Child Health and Human Development awarded Case Western Reserve University $350,286 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate androgen-estrogen balance and fibroblast growth factor pathways underlying sperm maturation in human efferent ducts. The project uses an innovative three-dimensional organoid culture model to explore the roles of the androgen receptor, estrogen receptor ESR1, and...
- The National Institutes of Health Office of the Director awarded a Cooperative Agreement totaling $3.262 million to the Massachusetts Institute of Technology on February 6, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to establish the NAMS Technology Development Center for Women's Health, a translational research platform targeting gynecology disorders including endometriosis, adenomyosis, heavy menstrual bleeding, and polycystic ovary syndrome. MIT will develop combinatorial...
- The National Institute of Child Health and Human Development awarded Case Western Reserve University $431,750 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on proteolytic cleavage of PR-B as a novel mechanism for functional progesterone withdrawal in human parturition, with specific focus on spontaneous preterm birth. Work is performed in Cleveland, Ohio through August 31, 2028. The recipient's Office of...
- The National Institute of Child Health and Human Development awarded Marshall University Research Corporation $147,500 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate epigenetic regulation of CXCR4 in endometriosis. The research examines aberrant promoter methylation dynamics of CXCR4, a master regulator involved in endometrial cell migration, stem cell trafficking, and lesion formation in endometriosis. The project aims...
- The National Institutes of Health Office of the Director awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $371,250 under the Trans-NIH Research Support program (CFDA 93.310) on July 20, 2026, to develop and test the feasibility and acceptability of EASE-ENDO, an eight-session live video mind-body group intervention for endometriosis-associated pain. EASE-ENDO integrates evidence-based skills from Acceptance and Commitment Therapy and Dialectical...
- The National Institutes of Health National Cancer Institute awarded the University of Pittsburgh $664,369 on August 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to define the mechanism by which endometriosis-derived mesenchymal stromal cells dysregulate iron homeostasis in ovarian clear cell cancer and to identify therapeutic targeting strategies. The award funds research examining how loss of CD10 in endometriotic stromal cells enables iron export to adjacent ovarian...
- The National Institutes of Health National Institute on Aging awarded $681,020 to Magee-Womens Research Institute and Foundation on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate microbial regulation of type 2 immunity in ovarian tissue remodeling and fibrosis. The research challenges the paradigm that reproductive decline results from inevitable follicle depletion, instead identifying ovarian tissue fibrosis as an environmentally modifiable process driven by...