Project Grant R01HD119005
- The National Institute of Child Health and Human Development awarded Case Western Reserve University $431,750 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on proteolytic cleavage of PR-B as a novel mechanism for functional progesterone withdrawal in human parturition, with specific focus on spontaneous preterm birth. Work is performed in Cleveland, Ohio through August 31, 2028. The recipient's Office of...
- The National Institute of Child Health and Human Development awarded Case Western Reserve University $149,190 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the molecular mechanisms governing cell fate transition and lineage commitment through H3K4ME1/2 demethylation. The recipient will dissect how the demethylase activity of LSD1 and LSD2 histone demethylases regulates gene expression and cellular differentiation using...
- The National Institute of Child Health and Human Development awarded $481,658 to Baylor College of Medicine on July 1, 2026, to support research into signaling pathways in testicular descent and function under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research addresses cryptorchidism (undescended testicles), a condition affecting 1–3 percent of full-term newborns. Despite surgical correction before age 2, nearly 50 percent of patients with...
- The National Institute of General Medical Sciences awarded Case Western Reserve University $431,750 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support data-driven structural characterization of the estrogen receptor and its domain interactions relevant to breast cancer therapeutics. The research comprises two integrated projects. Project 1 will characterize the structural properties of the estrogen receptor's N-terminal transactivation domain...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts Medical School $716,119 on July 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate dietary signaling mechanisms in male reproductive tissues and their epigenetic effects on offspring. The project explores how paternal dietary exposures influence cell composition and gene regulation in the testis, epididymis, and seminal vesicle, and...
- The National Institute of Child Health and Human Development awarded the University of South Florida $114,237 on June 5, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research dissecting estrogen receptor alpha (ERA) functions in anteroventral and periventricular medial preoptic area neurons co-expressing the long-form leptin receptor. The research examines how ERA signaling as a nuclear receptor and mRNA-binding protein—distinct from...
- The National Institute of Child Health and Human Development awarded Michigan State University $3.548 million on September 12, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct transcriptomic analyses of early endometriotic lesion development. The recipient, doing business as Henry Ford Health+Michigan State University Health Sciences, will integrate single-cell, spatial, and bulk transcriptomics analyses of peritoneal endometriotic lesions...
- The National Institutes of Health Office of the Director awarded Case Western Reserve University $235,500 under the Trans-NIH Research Support program (CFDA 93.310) on August 14, 2026. The award funds a research project investigating the relationship between the reproductive microbiome, neutrophil function, and endometriosis pathogenesis. The research will enroll a cohort of women undergoing diagnostic laparoscopy for pelvic pain or infertility, with approximately half receiving an endometriosis...
- The National Institute of Child Health and Human Development awarded The Washington University $922,870 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR). The award funds research to define the molecular mechanisms by which age-associated increases in ovarian tissue stiffness drive follicle inflammation and impair oocyte quality and fertility. The research tests the hypothesis that follicles detect age-related...
- The National Institute of Child Health and Human Development awarded University of Massachusetts Boston $577,974 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate RNA binding proteins in the maintenance of male fertility and spermatogenesis. The research uses zebrafish as a model organism to elucidate how RNA regulation by ADAD1 proteins controls spermatogonial stem cell maintenance and differentiation during continuous...
The National Institute of Child Health and Human Development awarded Case Western Reserve University $350,286 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate androgen-estrogen balance and fibroblast growth factor pathways underlying sperm maturation in human efferent ducts. The project uses an innovative three-dimensional organoid culture model to explore the roles of the androgen receptor, estrogen receptor ESR1, and FGF signaling in differentiation and function of human efferent ducts. Research activities include analyzing how physiological levels of dihydrotestosterone, testosterone, and 17-beta-estradiol contribute to efferent duct organoid development using RNA sequencing and chromatin immunoprecipitation sequencing to identify direct targets of androgen and estrogen-mediated gene expression, and examining the role of FGF signaling and stromal cell-secreted factors in organoid growth and morphology. The project also investigates how elevated estrogen levels and endocrine disruptors damage the epididymis epithelium using the organoid culture system. Performance runs through May 31, 2031, at Case Western Reserve University in Cleveland, Ohio. The award is structured as a Project Grant, the standard NIH research grant mechanism for investigator-initiated proposals evaluated through peer review for scientific merit, significance, innovation, investigator qualifications, and research environment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.3k | 9/2/26 |