Project Grant K08AT014014
- The National Institute of Child Health and Human Development awarded the University of Texas at Dallas $608,387 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate vaginal microbiome-nociceptor interactions in endometriosis pain. The research uses mouse models of endometriosis, intravaginal antibiotic treatment, vaginal microbiota transplant paradigms, and probiotic bacterial administration to explore the bidirectional...
- The National Institute of Neurological Disorders and Stroke awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $3.637 million on August 24, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify pro-resolving lipid mediator receptors as therapeutic targets for endometriosis-associated pain. The project runs through April 30, 2030, and is performed in Massachusetts. The research aims to identify the most active specialized...
- The National Institute of Neurological Disorders and Stroke awarded The McLean Hospital Corporation $468,368 on September 5, 2026, to investigate the relationship between gut microbiome composition, multisensory sensitivity, and pain experience in adolescent girls with primary dysmenorrhea under CFDA 93.279 (Drug Use and Addiction Research Programs). The project will evaluate how alterations in gut microbiome composition contribute to multisensory sensitivity—heightened sensitivity to...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Florida $603,019 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to optimize novel REV-ERB agonist compounds for treatment of chronic inflammatory pain. The funded research develops high-affinity REV-ERB agonists with demonstrated in vivo...
- The National Institutes of Health Office of the Director awarded Case Western Reserve University $235,500 under the Trans-NIH Research Support program (CFDA 93.310) on August 14, 2026. The award funds a research project investigating the relationship between the reproductive microbiome, neutrophil function, and endometriosis pathogenesis. The research will enroll a cohort of women undergoing diagnostic laparoscopy for pelvic pain or infertility, with approximately half receiving an endometriosis...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded the University of Michigan $2.97 million on August 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research on individual differences in brain morphology and connectivity related to endometriosis-associated pelvic pain (EAPP) in females. The research addresses treatment-refractory disease and comorbid conditions by synthesizing neuroimaging data from...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Florida $186,516 on August 12, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop nitrogen-vacancy diamond quantum magnetometry for endoscopic detection and mapping of iron accumulation in endometriosis tissue. The project establishes a quantum magnetic sensing platform integrating nitrogen-vacancy centers in...
- The National Institutes of Health Office of the Director awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $371,250 under the Trans-NIH Research Support program (CFDA 93.310) on July 20, 2026, to develop and test the feasibility and acceptability of EASE-ENDO, an eight-session live video mind-body group intervention for endometriosis-associated pain. EASE-ENDO integrates evidence-based skills from Acceptance and Commitment Therapy and Dialectical...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded the University of Florida $422,125 on July 21, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to identify and characterize novel analgesic compounds derived from plant- and animal-associated microorganisms. The project uses a zebrafish-based model for nociceptive pain to screen microbial metabolites from bacteria and fungi for analgesic activity....
- The National Institute of Child Health and Human Development awarded Oregon State University $444,498 on August 18, 2026, to develop nanoparticle-mediated chemodynamic therapy for endometriosis under the Child Health and Human Development Extramural Research program (CFDA 93.865, Project Grant R01HD121601). Endometriosis affects approximately 176 million women worldwide, causing severe pelvic pain and infertility with no cure. Current clinical therapies cause infertility, and surgical lesion...
The National Institute of Neurological Disorders and Stroke awarded the University of Florida $187,317 on July 20, 2026, to characterize the endometriosis microbiome and metabolomic pain phenotype under the Drug Use and Addiction Research Programs (CFDA 93.279). The project stratifies individuals with endometriosis into treatment-responsive groups by identifying differences in microbial and NAD+ metabolomic patterns associated with differing pain characteristics, quality of life, psychological symptoms, and postoperative outcomes. Work encompasses two specific aims: determining bacterial composition in stool, ovarian, and endometrial tissue that associates with differing endometriosis chronic pain phenotypes, and identifying dominant NAD+ biosynthetic pathways and alterations in NAD+ metabolites associated with chronic pain phenotypes in endometriosis and endometrial tissue. The research shifts focus from limited hormonal treatments and repetitive invasive surgical procedures toward the novel role of the microbiome and NAD+ metabolome on differing phenotypic pain presentations. Performance occurs in Gainesville, Florida, with a period of performance from July 20, 2026, through June 30, 2031. The award is classified as a Project Grant, a career development award supporting basic research in substance use and addiction, though the project scope centers on endometriosis pain mechanisms rather than drug use directly.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $187.3k | 7/21/26 |