Project Grant R21HD119415
- The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 project grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Ann & Robert H. Lurie Children's Hospital of Chicago. The grant, with a performance period from August 2025 to July 2027, supports research to investigate the role of the kynurenine pathway in the development of necrotizing enterocolitis (NEC), a serious gastrointestinal condition affecting...
- This federal Project Grant award, totaling $2,334,824.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The overriding goal of this 4-year grant, awarded to The Johns Hopkins University, is to understand the pathogenesis of neonatal necrotizing enterocolitis (NEC) - a leading cause of death from gastrointestinal disease in premature infants - and to develop...
- This $232,500 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to address the challenge of necrotizing enterocolitis (NEC), a life-threatening intestinal disease in premature infants. The grant will support research to define the efficacy of human-derived placental stem cell extracellular vesicles (HPSC-EV) as a potential cell-free therapy, determine the cellular and transcriptional changes in NEC disease and therapeutic repair, and...
- This federal Project Grant award, valued at $534,899.00 and running from June 1, 2025 to February 28, 2030, is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award aims to define the syndrome of combined methylmalonic acidemia and homocystinuria, cblC-type (CBLC) - an inborn error of cobalamin (vitamin B12) metabolism - as a neurocristopathy impacting...
- This federal Project Grant award of $630,847 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research conducted by Children's Mercy Hospital in Kansas City, Missouri to study the role of the SIGIRR gene in regulating intestinal barrier function and preventing necrotizing enterocolitis (NEC) in preterm infants. The key focus areas include...
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA program 93.865, "Child Health and Human Development Extramural Research," provides $430,031.00 to evaluate the role of DNA methylation changes in very early preterm birth. The grant, awarded to Harvard T.H. Chan School of Public Health, will support research activities focused on understanding the complex biological mechanisms underlying preterm birth, a critical public...
- This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to develop an early life phenotyping framework for very preterm infants. The research aims to create 'perinatal phenotypes' by integrating variables such as reason for preterm birth, intrapartum care, and neonatal presentation, and then determine how these phenotypes contribute to...
- The National Institute of Child Health and Human Development (NICHD) awarded a $398,750 Project Grant (CFDA 93.865) to the University of Oklahoma (OU) to conduct research on the role of creatine metabolism in necrotizing enterocolitis (NEC), a serious gastrointestinal disease affecting preterm infants. The research aims to test the hypotheses that creatine deficiency detrimentally affects preterm infant intestinal epithelial injury, while creatine supplementation can prevent NEC-like injury. The...
- This $160,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research supports research to understand fetal liver lipid metabolism under intrauterine growth restriction (IUGR) using a novel preeclampsia mouse model. The research aims to investigate the mechanisms linking IUGR to the development of adult non-alcoholic fatty liver disease (NAFLD), with a focus on the role of...
- This federal Project Grant award of $790,208.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by Beth Israel Deaconess Medical Center, Inc. (Bidmc) to predict the effect of obstetric unit closures on maternal and neonatal outcomes, with a focus on very preterm births. The award has an ultimate completion date of May 31, 2030. Bidmc, a...
The Project Grant award of $425,015 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to investigate the role of interindividual epigenetic variation in the development of necrotizing enterocolitis (NEC) in preterm infants. The two-year project, which commenced on August 1, 2025, will be conducted by Baylor College of Medicine, a prestigious private non-profit health sciences university in Texas. The key objectives of the project are to: 1) Determine if variation in constitutively methylated regions (CORSIVs) in peripheral blood leukocytes at birth is associated with the subsequent development of NEC in preterm infants, and 2) Investigate the relationship between blood leukocyte CORSIVs and the intestinal microbiome in preterm infants. The project will leverage a pilot nested case-control study of 11 NEC patients and 22 controls to analyze CORSIVs and perform methylation quantitative trait locus (mQTL) mapping.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $425.0k | 7/29/25 |