Project Grant R03DK144356
- This federal Project Grant award, totaling $2,334,824.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The overriding goal of this 4-year grant, awarded to The Johns Hopkins University, is to understand the pathogenesis of neonatal necrotizing enterocolitis (NEC) - a leading cause of death from gastrointestinal disease in premature infants - and to develop...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $234,000 in funding to Oregon Health & Science University to support research on the role of the IMP1 protein in regulating intestinal mucus composition and promoting survival during necrotizing enterocolitis (NEC) in premature infants. The project aims to define the impact of IMP1...
- The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 project grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Ann & Robert H. Lurie Children's Hospital of Chicago. The grant, with a performance period from August 2025 to July 2027, supports research to investigate the role of the kynurenine pathway in the development of necrotizing enterocolitis (NEC), a serious gastrointestinal condition affecting...
- This federal Project Grant award of $630,847 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research conducted by Children's Mercy Hospital in Kansas City, Missouri to study the role of the SIGIRR gene in regulating intestinal barrier function and preventing necrotizing enterocolitis (NEC) in preterm infants. The key focus areas include...
- The Project Grant award of $425,015 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to investigate the role of interindividual epigenetic variation in the development of necrotizing enterocolitis (NEC) in preterm infants. The two-year project, which commenced on August 1, 2025, will be conducted by Baylor College of Medicine, a prestigious private non-profit health sciences...
- This $2,618,975 Project Grant was awarded on September 8, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports a 5-year research project led by the University of Texas Health Science Center at Houston to advance the development and functional capabilities of tissue-engineered intestine as a potential cure...
- This $699,518 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a platform encapsulation technology for stabilizing probiotic strains in powders with high water activity. The goal is to improve the delivery and efficacy of probiotics for preventing necrotizing enterocolitis (NEC) in preterm infants. The awardee,...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $722,908 to The Children's Hospital of Philadelphia to conduct research aimed at finding new ways to prevent and treat Hirschsprung disease-associated enterocolitis (HAEC), a life-threatening bowel inflammation. The key goals are to analyze stool metabolites, stool microbes, and gut...
- This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is for the transformation of a human-induced pluripotent stem cell (iPSC)-derived bone marrow organoid to study hematopoiesis. The key objectives are to perform cellular mapping of the organoid, optimize it for the study of hematopoietic development, and culture the organoid under specific...
This $232,500 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to address the challenge of necrotizing enterocolitis (NEC), a life-threatening intestinal disease in premature infants. The grant will support research to define the efficacy of human-derived placental stem cell extracellular vesicles (HPSC-EV) as a potential cell-free therapy, determine the cellular and transcriptional changes in NEC disease and therapeutic repair, and establish a novel human NEC enteroid monolayer model system. This integrated characterization of in vivo NEC pathogenesis, in vivo HPSC-based therapeutic responses, and an in vitro human NEC model system is expected to elucidate unique cell-specific expression profiles of NEC disease and repair pathways, ultimately informing the development of improved interventions for this serious condition. The award period runs from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $232.5k | 8/18/25 |