Project Grant R21HD112659

Award Date 9/5/23
Completion Date 8/31/25
Dollars Obligated $399K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Oklahoma City, OK 73104, USA
Similar Awards
This Project Grant award, valued at $378,272 and provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 (Child Health and Human Development Extramural Research), will fund research to explore the use of inter-alpha inhibitor proteins (IAIP) as a potential therapeutic agent for necrotizing enterocolitis (NEC) - a serious inflammatory condition affecting premature infants. The research aims to obtain proof-of-concept for IAIP replacement...
This $725,077 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to study the immunopathogenesis of necrotizing enterocolitis (NEC) in preterm infants and develop innovative interventions to interrupt the deleterious inflammatory response that leads to this devastating intestinal disease. The primary recipient, the University of North Carolina at Chapel Hill, will leverage...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $174,114 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on signaling pathways that regulate intestinal epithelial cell injury in necrotizing enterocolitis (NEC), a devastating gastrointestinal disease that affects premature infants. The studies aim to...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is for a $683,916 project to develop a novel probiotic delivery system to prevent and treat neurodevelopmental impairment (NI) in premature infants. The central focus is on using a protective biofilm-encapsulated probiotic, Limosilactobacillus reuteri (LR), to mitigate the effects of necrotizing enterocolitis...
This Project Grant award of $630,847 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Children's Mercy Hospital in Kansas City, Missouri. The research aims to investigate how the genetic regulator SIGIRR promotes intestinal barrier function and prevents necrotizing enterocolitis (NEC), a life-threatening condition in preterm infants....
This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund a study to create a novel patient selection framework for early life interventions targeting infection, inflammation, and growth outcomes in very preterm infants. The study aims to leverage a registry of over 3,600 very preterm infants and their mothers to develop perinatal phenotypes that...
This $159,362 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to characterize how breast milk IgA shapes the development of the preterm infant gut microbiome and promotes resistance to pathobionts. The primary goals are to: 1) Determine if maternal IgA binding restricts colonization of Enterobacteriaceae and promotes the establishment of obligate anaerobes...
This $492,409 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program supports research to investigate the role of the creatine pathway in regulating intestinal goblet cell development and the impact on inflammatory bowel disease (IBD). The key objectives are to: 1) Evaluate the contribution of glycolysis on goblet cell differentiation and activity in creatine...
This $394,280 federal Project Grant award from the Agency for Healthcare Research and Quality (AHRQ) under the Research on Healthcare Costs, Quality and Outcomes (CFDA 93.226) program aims to reduce disparities in necrotizing enterocolitis (NEC) in premature infants through a Neonatal Project ECHO (NEOECHO) intervention. The project will evaluate the effectiveness of the NEOECHO approach in improving NEC-related outcomes and quality of care at 30 underserved neonatal intensive care units...
The federal grant award R00HD110605 for $600,914.01 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will support a research project titled "Neonatal Stress in Very Preterm Infants: Longitudinal Effects on Epigenetics and Neurodevelopment" over the period of September 1, 2024 to August 31, 2027. The project will be conducted by the University of Iowa,...

The National Institute of Child Health and Human Development (NICHD) awarded a $398,750 Project Grant (CFDA 93.865) to the University of Oklahoma (OU) to conduct research on the role of creatine metabolism in necrotizing enterocolitis (NEC), a serious gastrointestinal disease affecting preterm infants. The research aims to test the hypotheses that creatine deficiency detrimentally affects preterm infant intestinal epithelial injury, while creatine supplementation can prevent NEC-like injury. The project will also investigate the relationship between creatine metabolism and NEC development in preterm infants. Successful completion of this research is expected to introduce a novel treatment target for NEC, a condition for which there are currently no effective prophylactic alternatives or therapeutics beyond surgical intervention and supportive care. The award period is from September 5, 2023 to August 31, 2025.

Generated 8/13/24, 4:42 AM