Project Grant R01HD116761

Award Date 6/1/25
Completion Date 2/28/30
Dollars Obligated $535K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Texas, USA
Similar Awards
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $602,956 to the University of Alabama at Birmingham (UAB) to conduct research on the molecular mechanisms underlying ciliopathy-associated structural birth defects. The research aims to identify and characterize genetic variants that disrupt cilia function, leading to developmental disorders. Key...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $200,625 from March 1, 2025 to February 28, 2027 to the Childrens Hospital Medical Center in Cincinnati, Ohio. The grant will support research to determine the identity of a specific neural crest-derived cell lineage that interacts with an endocrine gland to regulate embryonic calcium uptake and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $486,750.00 to the Sloan-Kettering Institute for Cancer Research, a non-profit organization, to conduct research on the molecular and cellular pathways that drive competency for human vagal neural crest specification. The research aims to fully characterize the population of cells that exhibits...
The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant totaling $196,719 to Baylor College of Medicine to study how the loss of the CASK gene in inhibitory neurons contributes to intellectual disability and epilepsy in mouse models. The grant, which runs from September 15, 2024 to May 14, 2027, will support research to determine the synaptic changes in inhibitory neurons that result in the cognitive deficits and seizure activity observed in CASK-related...
This $617,704 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research into the role of highly similar intrachromosomal repeats (HSIRs) in the formation of copy number variants (CNVs) associated with genetic disorders. The key objectives are to: 1) identify nonrecurrent CNVs in disease cohorts and investigate HSIR features at breakpoint junctions; 2) examine how the genomic...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) in the amount of $668,211 will fund research to investigate the role of dysregulated RNA metabolism in maternal diabetes-induced neural tube defects (NTDs). The key products and services to be delivered through this 5-year award include: Determining whether the reduction of miR-322 expression, which is repressed by maternal...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $1,009,425.00 to The Curators of the University of Missouri, doing business as the University of Missouri at Kansas City (UMKC), to conduct research on the impact of maternal dietary vitamin A on the risk and severity of cleft lip/palate in genetically predisposed embryos. The research aims to...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $603,726 to fund a research project focused on improving the identification of genetic contributors to rare neurodevelopmental disorders in children. The key products and services to be delivered under this award include: 1) sequencing the genomes of 500 affected individuals using advanced...
This $760,617 federal Project Grant award was provided by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The grant supports research to identify key transcription factors and dissect the mechanisms underlying the transitions between pre-pluripotent, naive, and formative pluripotent states in the inner...
This $160,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research supports research to understand fetal liver lipid metabolism under intrauterine growth restriction (IUGR) using a novel preeclampsia mouse model. The research aims to investigate the mechanisms linking IUGR to the development of adult non-alcoholic fatty liver disease (NAFLD), with a focus on the role of...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $534,899 to Baylor College of Medicine to conduct research on the role of vitamin B12-dependent metabolic pathways in neural crest development. The project aims to use novel mouse models to identify which specific cobalamin-dependent pathways, when disrupted, lead to neural crest developmental defects, as well as investigate whether modulating the maternal environment can improve the phenotypic presentation of the resulting congenital disorder known as combined methylmalonic acidemia and homocystinuria, cblC-type (CBLC). The findings from this 5-year research project, which runs from June 1, 2025 to February 28, 2030, are expected to shed light on the pathophysiology of CBLC and potentially inform future patient treatment approaches.

Generated 6/17/25, 4:07 AM