Project Grant R21HD118656
- The National Institute of Mental Health awarded Cincinnati Children's Hospital Medical Center $723,817 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study fragile X syndrome–associated blood-brain barrier defects and hypervascularization using blood-brain barrier assembloid models derived from patient-induced pluripotent stem cells. The research develops and validates BBB assembloid models combining neural and vascular components from fragile X syndrome and...
- The National Institute of Child Health and Human Development awarded $429,000 to The Regents Of The University Of Colorado (University of Colorado-Denver) on August 14, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize Fragile X Syndrome in the human brain using post-mortem human tissue. The research team will study cell-type-specific gene expression in Fragile X Syndrome human brain tissue and investigate length and methylation...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Cincinnati Children's Hospital Medical Center a $900,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on September 18, 2025, with an ultimate completion date of August 31, 2030. This mechanistic and translational medicine research initiative addresses critical knowledge gaps in Fragile X Syndrome (FXS) by establishing...
- The National Institute of Child Health and Human Development awarded $3.231 million to Regents of the University of Michigan on September 11, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support Fragile X Premutations, Mechanisms and Modifiers research conducted in Michigan. The award funds three integrated research projects addressing genetic, pathologic, and environmental factors underlying premutation-associated Fragile X...
- The National Institute of Mental Health awarded The Children's Hospital Corporation (Boston Children's Hospital) $497,364 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on therapeutic targeting of proteostasis in Fragile X Syndrome. The work investigates protein degradation mechanisms in Fragile X Syndrome and tests proteasome inhibition as a novel therapeutic strategy. The research interrogates whether increased ubiquitin proteasome system...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $739,125 for a project grant to decipher the molecular function of fragile X messenger ribonucleoprotein (FMRP) in fragile X syndrome, awarded on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242). The project investigates FMRP's role in translational regulation and its relationship to fragile X syndrome pathogenesis. Fragile X syndrome, the most prevalent form of inherited...
- The National Institute of Child Health and Human Development awarded New York University $227,652 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate astrocytic regulation of neuronal physiology in Fragile X Syndrome. The research applies ribosome profiling and astrocyte-specific secreted proteomics to identify changes to astrocyte protein synthesis and secretion following FMRP loss, and uses co-culture of human neurons in...
- Federal Project Grant Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $425,628 project grant to the Regents of the University of California at Riverside on August 1, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a two-year research initiative (through July 31, 2027) investigating the molecular mechanisms by which mutations in the Fragile X Messenger Ribonuclein 1...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $824,998 under Project Grant R01MH137056 on June 1, 2026, to investigate r-loop-induced CGG contraction as a therapeutic approach for Fragile X Syndrome. The funded research examines how two compounds—a MEK inhibitor and a BRAF inhibitor—reactivate the silenced FMR1 gene by promoting DNA demethylation and forming site-specific r-loops that recruit endogenous DNA repair mechanisms...
- The Centers for Disease Control and Prevention awarded the National Fragile X Foundation a $200,000 cooperative agreement on September 30, 2026, under the Disabilities Prevention program (CFDA 93.184) to translate research findings into practical educational and support resources for people with Fragile X syndrome, their families, and healthcare providers. The Foundation will update and expand its existing collection of Fragile X resources to reflect current evidence, conduct needs...
The National Institute of Child Health and Human Development awarded Cincinnati Children's Hospital Medical Center $445,500 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and test genetic and molecular assays for predicting disease severity in Fragile X Syndrome. The research addresses the absence of early quantitative biomarkers that currently prevent individualized therapeutic strategies for FXS patients. The project leverages long-read sequencing and highly sensitive assays to evaluate potential predictors of disease severity and outcomes. The investigators have optimized an assay that detects FMRP (Fragile X Messenger Ribonucleoprotein) levels in peripheral blood across a wide range, including low levels in approximately 50 percent of full mutation, fully methylated males who are assumed under current diagnostic standards to express no FMRP at all. Preliminary findings show that higher FMRP levels correlate with higher IQ scores, establishing clinical significance for the molecular measures being developed. The period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in Cincinnati, Ohio. This is a Project Grant, the standard NIH research project assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.5k | 8/12/26 |