Project Grant R01MH143987
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $824,998 under Project Grant R01MH137056 on June 1, 2026, to investigate r-loop-induced CGG contraction as a therapeutic approach for Fragile X Syndrome. The funded research examines how two compounds—a MEK inhibitor and a BRAF inhibitor—reactivate the silenced FMR1 gene by promoting DNA demethylation and forming site-specific r-loops that recruit endogenous DNA repair mechanisms...
- The National Institute of Mental Health awarded Cincinnati Children's Hospital Medical Center $723,817 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study fragile X syndrome–associated blood-brain barrier defects and hypervascularization using blood-brain barrier assembloid models derived from patient-induced pluripotent stem cells. The research develops and validates BBB assembloid models combining neural and vascular components from fragile X syndrome and...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $739,125 for a project grant to decipher the molecular function of fragile X messenger ribonucleoprotein (FMRP) in fragile X syndrome, awarded on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242). The project investigates FMRP's role in translational regulation and its relationship to fragile X syndrome pathogenesis. Fragile X syndrome, the most prevalent form of inherited...
- The National Institute of Child Health and Human Development awarded $429,000 to The Regents Of The University Of Colorado (University of Colorado-Denver) on August 14, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize Fragile X Syndrome in the human brain using post-mortem human tissue. The research team will study cell-type-specific gene expression in Fragile X Syndrome human brain tissue and investigate length and methylation...
- The National Institute of Mental Health awarded Emory University $430,375 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct spatial translational dysregulation research in Fragile X Syndrome. The award funds construction of high-resolution, single-cell maps of translational regulation in Fragile X Syndrome mouse brains using advanced spatial genomics technologies including STARMAP-PLUS and RIBOMAP. Research aims include generating spatial transcriptomics...
- The National Institute of Child Health and Human Development awarded Cincinnati Children's Hospital Medical Center $445,500 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and test genetic and molecular assays for predicting disease severity in Fragile X Syndrome. The research addresses the absence of early quantitative biomarkers that currently prevent individualized therapeutic strategies for FXS patients. The project...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $162,560 on February 4, 2027, under the Mental Health Research Grants program (CFDA 93.242) to define molecular pathways in monoamine circuit development using autism-related syndrome genes in zebrafish. The recipient will conduct behavioral assays, sequencing, and imaging of monoamine circuits and brain-wide activity changes in zebrafish with mutations in genes associated with autism-related...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Cincinnati Children's Hospital Medical Center a $900,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on September 18, 2025, with an ultimate completion date of August 31, 2030. This mechanistic and translational medicine research initiative addresses critical knowledge gaps in Fragile X Syndrome (FXS) by establishing...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Boston Children's Hospital $577,573 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds functional validation of candidate genes implicated in refractory focal epilepsy, with emphasis on mosaic variants in mTOR pathway genes and non-mTOR genes such as SLC35A2. Boston Children's...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 6, 2026. The funded research quantifies folate receptor binding potential in the human choroid plexus using MRI-PET imaging. The work addresses a critical gap in understanding cerebral folate transport in autism spectrum disorder,...
The National Institute of Mental Health awarded The Children's Hospital Corporation (Boston Children's Hospital) $497,364 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on therapeutic targeting of proteostasis in Fragile X Syndrome. The work investigates protein degradation mechanisms in Fragile X Syndrome and tests proteasome inhibition as a novel therapeutic strategy. The research interrogates whether increased ubiquitin proteasome system activity in FMR1-knockout neurons is driven by excessive translation of aberrant proteins, determines the link between accelerated protein degradation and neuronal hyperexcitability (specifically testing whether misfolding and degradation of GABA-A receptors contributes to hyperexcitability), and investigates whether proteasome inhibition resolves hippocampal and cortical plasticity phenotypes in the FMR1-knockout mouse model of the disorder. The award period runs from August 1, 2026, through April 30, 2031, with performance in Boston, Massachusetts. This is a Project Grant, the standard NIH R01 award mechanism supporting specified project periods of up to five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $497.4k | 7/21/26 |