Project Grant P50HD118717
Award Date 9/18/25
Completion Date 8/31/30
Dollars Obligated $900K
Funding Federal Agency
Awarding Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Cincinnati, OH 45229, USA
Similar Awards
- This federal Project Grant award of $430,375.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research on membrane trafficking impairments in Fragile X Syndrome. The research aims to investigate the underlying mechanisms by which the loss of the FMRP protein in Fragile X Syndrome leads to dysregulated surface expression of membrane proteins, which is believed...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $187,500.00 to the University of South Florida to explore the role of the signaling protein Reelin in Fragile X Syndrome (FXS). The research aims to validate the use of a gene therapy approach to restore cognitive deficits in an FXS mouse model, as well as determine the mechanism...
- This $836,125.47 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to understand the molecular mechanisms governing lymphatic dysfunction in a mouse model of neurodevelopmental disorder, specifically Fragile X Syndrome (FXS). The research project will: 1) Determine how the FMR1 gene regulates meningeal lymphatic function, 2) Decipher the role of FMR1-induced lymphatic dysfunction in interferon gamma (IFNγ) T...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $515,898.00 to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) division to conduct research on the contribution of astrocytes, a type of glial cell, to sleep/wake disturbances in Fragile X Syndrome (FXS). The key...
- This $579,294 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the cell type-specific epigenetic mechanisms, particularly involving microRNAs, that regulate brain function and contribute to neurological disorders like epilepsy. The research aims to reveal the specific cell types and target mRNAs...
- The Washington University Office of Sponsored Research Services Division received a $427,625 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to unravel the role of satellite glial cells in sensory hypersensitivity in Fragile X Syndrome, a leading genetic cause of autism spectrum disorders. Key activities include: Examining how...
- This $1,615,502 federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports a comprehensive research initiative focused on advancing scientific understanding of fragile X-associated conditions (FXACs). The five-year research project led by the Regents of the University of Michigan aims to achieve a deeper understanding of the genetic,...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,724 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Regents of the University of California, San Francisco (UCSF) on January 23, 2025. The project, titled "Hypoxia-Induced Misdirection: Understanding Postnatal Inhibitory Interneuron Migration in Neonatal Hypoxic Injury", aims to use computational approaches to identify altered...
- This federal Project Grant award of $390,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of dysregulated eIF4E-mediated translational control in the pathogenesis of Focal Cortical Dysplasia Type II (FCDII), a neurodevelopmental disorder that causes focal cortical malformations and drug-resistant epilepsy. The...
- This $147,486 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the disease mechanism and develop gene therapy for a common and understudied STXBP1 missense variant that causes severe developmental and epileptic encephalopathy. The applicant has established a mouse model that recapitulates key neurological symptoms of this...