Project Grant R01MH139631
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $824,998 under Project Grant R01MH137056 on June 1, 2026, to investigate r-loop-induced CGG contraction as a therapeutic approach for Fragile X Syndrome. The funded research examines how two compounds—a MEK inhibitor and a BRAF inhibitor—reactivate the silenced FMR1 gene by promoting DNA demethylation and forming site-specific r-loops that recruit endogenous DNA repair mechanisms...
- The National Institute of Mental Health awarded Emory University $430,375 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct spatial translational dysregulation research in Fragile X Syndrome. The award funds construction of high-resolution, single-cell maps of translational regulation in Fragile X Syndrome mouse brains using advanced spatial genomics technologies including STARMAP-PLUS and RIBOMAP. Research aims include generating spatial transcriptomics...
- The National Institute of Child Health and Human Development awarded $429,000 to The Regents Of The University Of Colorado (University of Colorado-Denver) on August 14, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize Fragile X Syndrome in the human brain using post-mortem human tissue. The research team will study cell-type-specific gene expression in Fragile X Syndrome human brain tissue and investigate length and methylation...
- The National Institute of Mental Health awarded The Children's Hospital Corporation (Boston Children's Hospital) $497,364 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on therapeutic targeting of proteostasis in Fragile X Syndrome. The work investigates protein degradation mechanisms in Fragile X Syndrome and tests proteasome inhibition as a novel therapeutic strategy. The research interrogates whether increased ubiquitin proteasome system...
- The National Institute of Mental Health awarded Cincinnati Children's Hospital Medical Center $723,817 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study fragile X syndrome–associated blood-brain barrier defects and hypervascularization using blood-brain barrier assembloid models derived from patient-induced pluripotent stem cells. The research develops and validates BBB assembloid models combining neural and vascular components from fragile X syndrome and...
- The National Institute of Mental Health awarded Michigan State University $416,859 on March 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to probe nucleolus function in a mouse model of Fragile X Syndrome. The research aims to explore nucleolar hyper-function as a novel aspect of FXS pathology. The investigator proposes that this hyper-function drives aberrant ribosome biogenesis, thereby increasing cellular translation capacity and explaining the elevated global protein...
- The National Institute of Child Health and Human Development awarded Cincinnati Children's Hospital Medical Center $445,500 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and test genetic and molecular assays for predicting disease severity in Fragile X Syndrome. The research addresses the absence of early quantitative biomarkers that currently prevent individualized therapeutic strategies for FXS patients. The project...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded $619,977 to the University of Colorado-Denver on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate patterns and mechanisms of repeat instability in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS). The award funds research applying cutting-edge sequencing and analytic approaches to interrogate neurogenetic mechanisms of FMR1...
- The National Institute of Child Health and Human Development awarded $3.231 million to Regents of the University of Michigan on September 11, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support Fragile X Premutations, Mechanisms and Modifiers research conducted in Michigan. The award funds three integrated research projects addressing genetic, pathologic, and environmental factors underlying premutation-associated Fragile X...
- Federal Project Grant Award Summary Emory University received a $430,375 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded July 1, 2025, with completion expected June 30, 2027. This award funds research investigating membrane trafficking impairments in Fragile X Syndrome (FXS), the most common form of inherited intellectual disability and...
The National Institute of Mental Health awarded The Leland Stanford Junior University $739,125 for a project grant to decipher the molecular function of fragile X messenger ribonucleoprotein (FMRP) in fragile X syndrome, awarded on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242). The project investigates FMRP's role in translational regulation and its relationship to fragile X syndrome pathogenesis. Fragile X syndrome, the most prevalent form of inherited intellectual disability and a primary genetic cause of autism, arises from CGG repeat expansions or mutations in the FMR1 gene. Current clinical approaches targeting aberrant translational upregulation of FMRP target transcripts have not yielded clinical benefit, and recent ribosome profiling studies suggest FMRP may have a positive role in mRNA translation regulation. The research aims to clarify the mode of translational regulation by FMRP and investigate novel pathogenic mechanisms of the disease. Work is performed at Stanford's Palo Alto, California location. The period of performance extends from August 1, 2026 through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $739.1k | 7/31/26 |