This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $424,600.00 to The Leland Stanford Junior University to conduct research on the cellular mechanisms and microenvironment of the vagina in women with recurrent pelvic organ prolapse (POP) after previous POP surgery. The research aims to 1) examine the effects of POP surgery on the human vagina through tissue biomechanical testing, histology, and gene/protein analysis, and 2) investigate altered vaginal fibroblast function in recurrent vaginal prolapse after POP surgery, including cellular gene/protein expression, secreted proteins, and fibroblast response to TGF-β1. This foundational research is intended to generate new insights into the vaginal landscape after failed POP surgery, which is critical for developing effective treatments to address high recurrence rates of vaginal prolapse. The project period is from July 1, 2025 to June 30, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $424.6k | 6/17/25 |