The National Institute on Aging (NIA) awarded a $1,132,258 Project Grant (CFDA 93.866 - Aging Research) to Moremme VA LLC to develop a hormone-free, prebiotic, muco-adhesive gel for the treatment of vaginal atrophy in post-menopausal women. The goal is to optimize the loading and release of natural bioactives in the gel formulation, assess its safety and tolerability using human vaginal tissue models, and evaluate its efficacy in reversing signs of vaginal atrophy in animal studies. Upon...
The National Institute on Aging (NIA) awarded a $391,101 Project Grant under the Aging Research program (CFDA 93.866) to The Ohio State University to develop a novel nonsteroidal and nonhormonal agent that reverses menopause-related loss of genital epithelial integrity and function. The research aims to define the mechanism of action, optimize delivery, and establish the long-term safety profile of an EFNA3-mimetic agonist peptide (EFNA3-MAP) administered intravaginally to restore genital...
The University of Texas at Dallas received a $734,639 Project Grant (CFDA 93.866 - Aging Research) from the National Institute on Aging to conduct research on identifying age and injury-dependent mechanisms of elastic fiber dynamics in the murine vagina. The goal is to determine how age and vaginal injury impact the production and function of elastic fibers, which are critical for maintaining vaginal integrity and healing. The research will explore the use of the drug minoxidil to induce elastic...
The National Institute of Child Health and Human Development (NICHD) awarded Madorra Inc., a woman-owned small business, a $1,514,498 SBIR Direct-to-Phase II Project Grant (CFDA 93.865) to develop an at-home, non-hormonal ultrasonic device for the treatment of vulvovaginal atrophy (VVA). VVA affects up to 90% of peri- and postmenopausal women, as well as many breast cancer survivors receiving estrogen-suppressing treatments. The project aims to 1) update the Madorra Therapy System design to...
This $625,898 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop spatially-informed, cell-specific metabolic models of the ovary to identify novel biomarkers associated with the onset and duration of the menopause transition. The key products and services to be delivered include: Generation of spatially-informed, cell-specific, multicellular genome-scale metabolic models (GMMs) of the ovary using single-cell and spatial transcriptomics data...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $298,883 to Iaterion, Inc. to develop a safer menopausal hormone therapy (MHT) formula that can be used long-term to treat protracted menopausal symptoms and prevent chronic diseases like osteoporosis, diabetes, obesity, and metabolic syndrome. The project aims to create an estradiol/reprogramming ligand combination that can potentially replace the progestin component of current MHT...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $878,256 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Novagyn LLC, a woman-owned small business in New Hampshire. The goal of this Phase I STTR project is to establish the feasibility of a naturally-derived, coaxial electrospun scaffold as an alternative to synthetic surgical mesh for treating stress urinary incontinence in women. The project...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $451,000 in funding to The University of Texas Southwestern Medical Center to investigate how estrogen modulates chondrocyte mechanotransduction via the PIEZO1 and TRPV4 channels. The research aims to define the sex-specific and estrogen-regulated role of these mechanosensitive channels in chondrocyte mechanotransduction, which may help identify new targets to treat and prevent...
This $717,285 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund a large-scale investigation of the vaginal ecosystem and its potential role in preeclampsia. The project aims to uncover the microbial, metabolomic, and immune properties of the vaginal microbiome that may indicate, predispose to, or contribute to the development of preeclampsia, a serious...
The National Institute on Aging (NIA) awarded a $439,535 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Colorado from September 30, 2023 to September 29, 2025. This grant will fund research to investigate the interplay between active smooth muscle cell contractility and passive extracellular matrix mechanics in the aging bladder, with the goal of gaining insight into the development of lower urinary tract symptoms in older adults. The University...
This Project Grant award of $2,495,639.00 from the National Institute on Aging (NIA) Aging Research program (CFDA 93.866) aims to develop a regenerative biomaterial therapy to treat Genitourinary Syndrome of Menopause (GSM), a highly prevalent condition affecting up to 85% of perimenopausal and menopausal women. The principal investigator at the University of California, San Diego will create a novel vaginal tissue-derived extracellular matrix hydrogel (VECM) and assess its efficacy in reversing vaginal atrophy and restoring healthy vaginal function in a preclinical GSM model. The project involves a sub-award to Virginia Polytechnic Institute & State University to conduct mechanical characterization of vaginal tissue and contribute to the development of the biomaterial. The goal is to develop a safe, accessible, and minimally invasive regenerative therapy that can alleviate GSM symptoms and restore vaginal health for millions of affected women.