Project Grant K23HD115837

Award Date 7/15/24
Completion Date 6/30/29
Dollars Obligated $166K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Stanford, CA 94305, USA
Similar Awards
This $235,803 Project Grant award from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of a bioengineered 3D human myometrium model to quantify the kinetics of oxytocin-induced uterine smooth muscle contractility. The research, conducted by the Texas A&M Engineering Experiment Station, aims to establish a new method for directly evaluating myometrial contractility...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,526,336.00 to The Washington University in St. Louis to conduct research on improving the dosing and management of oxytocin during labor induction. The key objectives of this 5-year project are to: 1) develop a predictive model for successful labor induction using advanced measures of uterine...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $524,037 to Baylor College of Medicine to investigate the neurobiological mechanisms by which the TRPC5 ion channel regulates maternal behavior in mice. The research objectives are to: 1) test the hypothesis that TRPC5 maintains maternal behavior via activating oxytocin neurons in the hypothalamus, and...
This federal Project Grant award of $253,066 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research at The Washington University to investigate the impact of induced labor using oxytocin on the development of the oxytocinergic system and neurobehavior in offspring. The key objectives are to: 1) comprehensively map the developmental trajectory of the oxytocin receptor system in the postnatal...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to characterize the multiscale mechanisms of pregnancy-induced remodeling of pelvic floor muscles (PFMs) in order to promote understanding of vaginal birth biomechanics and injury prevention. The $117,959 award, effective from August 1, 2024 to July 31, 2026, will fund experimental and computational...
This Project Grant award, valued at $1,474,108.00 and spanning from July 1, 2024 to March 31, 2029, is funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research project aims to elucidate the cellular and molecular mechanisms underlying placenta accreta, a serious maternal condition characterized by excessive placental invasion into the uterus, often due to previous uterine...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports the development of a novel, uterine-targeted drug delivery system to treat preterm labor, a leading cause of neonatal mortality. The $126,568 award to Vanderbilt University will fund research to improve the encapsulation efficiency and antibody targeting of the drug delivery system, as well as evaluate its in vivo...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $1,829,617 to the University of California, San Diego (UCSD) for a project titled "STEM CELL-BASED MODELING OF PLACENTAL DEFECTS ASSOCIATED WITH EARLY-ONSET PREECLAMPSIA." The project aims to establish stem cell-based models for studying abnormal trophoblast differentiation and function...
The Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $170,420.00 to New York University School of Medicine to conduct research aimed at optimizing decision-making to improve maternal outcomes in high-risk pregnant patients with hypertensive disorders. The key objectives of the research project are to: 1) use a large dataset to compare maternal health...
This $584,074 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate the roles of the ion channel subunits Cav1.2 and Cav1.3 in uterine smooth muscle cell function, uterine peristalsis, and their relationship to fertility and the uterine disease adenomyosis. The research aims to provide a fundamental understanding of uterine peristalsis...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is funding research to elucidate the mechanisms by which oxytocin induces uterine contractility and how this process is disrupted in uterine atony, a leading cause of postpartum hemorrhage (PPH).

The $165,672 award to The Leland Stanford Junior University will support innovative translational research using human uterine tissue and cell cultures from cohorts with normal and impaired uterine contractility. The research aims to determine the functional relationship between oxytocin and the TRPV4 calcium channel in normal uterine contractility, as well as define the TRPV4-dependent and independent mechanisms underlying uterine atony. This knowledge could inform the development of novel, targeted treatments for uterine atony and PPH, a major global cause of maternal morbidity and mortality. The award period runs from July 2024 through June 2029.

Generated 6/17/25, 5:37 AM