Project Grant R01HD119238
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
- This federal Project Grant award of $128,898 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to elucidate how the 3D genome regulates the transcriptional program during mouse spermatogenesis, with the goal of providing insight into how male germ cell identity is established. The principal investigator will perform high-resolution Hi-C analysis...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on identifying novel noncoding genetic mechanisms that contribute to developmental disorders. The $499,055.48 award, with a project period from November 1, 2024 to October 31, 2027, will fund research led by Dr. Chelsea Lowther at the Icahn School of Medicine at Mount...
- The federal Project Grant award of $561,097 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research by Yale University to investigate the genetic basis and molecular mechanisms underlying reduced sperm motility, a leading cause of male infertility. The research aims to capitalize on the university's access to large consanguineous Pakistani families with abnormal semen...
- This Project Grant award of $128,214 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research at the University of Michigan to investigate how maternal and paternal centromeric protein levels are balanced during the first cell cycle of mammalian embryogenesis. The overarching objective is to understand the molecular mechanisms that equalize the...
- This Project Grant award of $248,994 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which administers the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award will fund research by the Washington University in New York, NY to investigate the mechanisms by which histone mutations affect chromatin structure, gene expression, and neural differentiation during development. The goal is to...
- This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
- The Trustees of Columbia University in the City of New York was awarded a $638,625.00 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) on August 21, 2025. The project, titled "In Vivo Regulation of Progenitor Genome Organization and Cellular Diversity", aims to investigate how the physical organization of the genome in neural progenitor cells impacts their ability to generate diverse neuronal subtypes during brain...
- This Project Grant award of $225,324, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the role of mitochondrial specialization in early development. The project aims to investigate how the mitochondrial electron transport chain (ETC) is regulated to meet the varying energetic and signaling demands of embryogenesis, using the C. elegans model...
This $616,841 project grant was awarded by the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", to Yale University beginning on August 15, 2025 and scheduled for completion on April 30, 2030. The project aims to investigate the molecular mechanisms that regulate genome activation and gene expression during embryonic development in vertebrates, with a focus on understanding how specific factors contribute to the establishment of 3D genome architecture and enhancer-promoter communication. The research leverages advanced techniques developed by the researchers, including expansion microscopy, to study these processes with unprecedented resolution in zebrafish embryos. The findings are expected to provide critical insights into the relationship between chromatin structure and gene regulation that underpin proper developmental programming, with broader implications for understanding reproductive health, fertility, and developmental disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/17/25 | ||
| Not listed | $616.8k | 8/14/25 |