This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $421,067 to the University of North Carolina at Chapel Hill to investigate the effects of in utero exposures, such as pregestational diabetes, on kidney development using human kidney organoids. The research aims to 1) examine the impact of the pregestational diabetic environment on the differentiation...
The Department of Health and Human Services National Institutes of Health (NIH) awarded Duke University a $1,425,761 Project Grant under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The purpose of this 3-year award is to harness stem cells and synthetic gene circuits to repair glomerular injury and address the significant burden of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in the U.S. and worldwide. The research will leverage Duke's expertise in...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $125,000.00 to the Whitehead Institute for Biomedical Research to support research on spatially-resolved, integrated cell state and lineage tracing in early mouse development. The goal is to delineate how progenitor cell behaviors and interactions lead to specific developmental phenotypes in health and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $718,499 to the University of Georgia Research Foundation to investigate adrenal gland development and disorders using human pluripotent stem cell-derived 2D and 3D models. The key objectives are to: 1) differentiate neural crest and Schwann cell progenitor-derived chromaffin cells in 2D and 3D to assess...
This federal Project Grant award, totaling $700,619, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this research project is to study and control the rhythmic formation of nephrons (functional units of the kidney) in kidney organoids derived from human induced pluripotent stem cells. The proposed research aims to: 1) determine the coordination of...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886 to The University of Texas Southwestern Medical Center to conduct research on elucidating the role of NAD+ and PARP1 in nephron endowment and kidney development. The 5-year research project aims to study how maternal NAD+ availability and cellular compartmentalization impact...
This Project Grant award of $358,062 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand kidney endothelial maturity and mesenchymal transition in vascularized human kidney organoids. The research aims to: 1) examine whether kidney organoid co-culture enables the induction of kidney-specific endothelial maturation, and 2) determine if...
The federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $104,838 to Duke University to conduct research on understanding how cells interpret and respond to varying inputs from the BMP signaling pathway, which plays a critical role in embryonic development and tissue health. The key products or services to be delivered under this award include:...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $464,940 to support a 5-year career development program for Dr. Elizabeth Nguyen at Seattle Children's Research Institute. The goal is to establish Dr. Nguyen as an independent academic investigator in epigenetics and kidney regeneration research. The key products or services to be...
This federal Project Grant award of $141,288 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the "Training Program in Organogenesis" at the University of Michigan. The program aims to provide a unique, multidisciplinary training experience for 6 predoctoral trainees, plus institutional support for 2 additional trainees, in the fields of developmental biology, stem...