This $154,980 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at Seattle Children's Hospital, doing business as Seattle Children's Research Institute, to study epigenetic regulation of kidney regeneration. The award provides career development training for Dr. Elizabeth Nguyen, a pediatric nephrologist, to establish an independent research program investigating mechanisms that promote kidney regeneration in the African spiny mouse. The research aims to define proximal tubule cell states during kidney regeneration, construct gene regulatory networks controlling proximal tubule cell regeneration, and identify critical epigenetic mechanisms driving kidney regeneration, with a focus on the YAP-TEAD pathway. This career development award will equip Dr. Nguyen with advanced skills in epigenetics, regeneration biology, and kidney injury models to build the foundation for a successful independent research career and a future R01 proposal in this area.
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