This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $358,062 to the University of Pittsburgh to conduct research on understanding kidney endothelial maturity and mesenchymal transition in vascularized human kidney organoids. The key objectives are to: 1) Determine if kidney organoid co-culture enables the induction of kidney-specific...
The federal Project Grant award R01DK140070, in the amount of $700,619, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The goal of this 4-year award is to study and control rhythmic nephron induction for kidney replacement tissues. The research aims to gain temporal control over rhythmic nephron formation in human induced pluripotent stem cell-derived kidney...
This federal Project Grant award of $427,625.00 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports a 2-year research project at the University of North Carolina at Chapel Hill to redefine the cellular origins of the kidney's intermediate mesoderm and investigate how it develops. The key objectives are to: 1) Perform novel lineage...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $436,277 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS" aims to develop an easy-to-use 3D in vitro model of the developing nephron that allows spatial patterning...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
The Department of Health and Human Services National Institutes of Health (NIH) awarded Duke University a $1,425,761 Project Grant under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The purpose of this 3-year award is to harness stem cells and synthetic gene circuits to repair glomerular injury and address the significant burden of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in the U.S. and worldwide. The research will leverage Duke's expertise in...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to quantify the impact of hyperglycemia on embryonic metabolism and development in C. elegans. The $474,878 award to the Children's Hospital Medical Center in Cincinnati, Ohio will support a 2-year research project to generate single-cell resolution data on how embryonic metabolism changes over developmental...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on enhancing the metabolic maturity of human pluripotent stem cell-derived islet organoids for improved transplantation outcomes in type 1 diabetes. The $681,562 award, granted on July 21, 2025, will support research at the University of Michigan to investigate pharmacological and 3D...
This $194,380 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to study the role of the protein LIM-nebulette in helping podocytes (kidney cells) adapt to mechanical stress, such as that caused by severe hypertension. The grantee, Icahn School of Medicine at Mount Sinai, will use a novel mechanical stretch platform and high-content image analysis to understand how...