This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), will support research to characterize the molecular interactions of RNA-binding proteins (RBPs) and how they drive post-transcriptional gene expression changes during embryonic stem cell differentiation. The $1,102,648 award, made to The Trustees of Columbia University in the City of New York, will leverage novel...
This $411,250 five-year Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The objective is to investigate the mechanisms by which RNA-DNA hybrid structures called R-loops epigenetically regulate gene transcription in pluripotency, early development, and tissue homeostasis. The research aims to establish a coherent understanding of R-loops as DNA and histone epigenetic...
The National Institutes of Health (NIH) Office of the Director awarded a $1,463,997 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Trustees of Columbia University in the City of New York, Health Sciences Division. The grant, which runs from September 1, 2024 to August 31, 2027, will fund the development of a "Programmable Depletion and Rescue Platform to Screen Dynamic Regulatory Events During Cellular Differentiation." This innovative platform aims...
This $454,717 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate how the three-dimensional organization of the genome in neural progenitor cells (neuroblasts) relates to gene expression and cell identity during brain development. The primary awardee, The Trustees of Columbia University in the City of New York, will purify neuroblasts at different developmental...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $378,123 to the Research Foundation of the City University of New York (RFCUNY) to identify and test mechanisms that establish the transcriptional regulatory potency of early embryos. The project aims to investigate the relationships among DNA accessibility, nucleosome lability, transcription,...
This Project Grant award in the amount of $148,568.00 was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award aims to identify the developmental mechanisms by which adult pluripotent stem cells (APSCs) are formed and maintained in highly regenerative animal species. The key objectives are to: (1) determine the molecular trajectory of APSC formation, (2) define the chromatin landscape...
This $393,093 Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the interaction between gene expression, cell morphology, and tissue-level mechanics in developmental processes. The 5-year award, effective February 1, 2025, will be used to: 1) Identify gene expression programs that predict tensional dynamics in multi-species, spatio-temporal developmental contexts,...
This $1,576,519 federal Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the role of the METTL3 gene in mammalian placental development and function. The research aims to study the importance of METTL3, which catalyzes an RNA modification, in trophoblast progenitor cell self-renewal, differentiation, and placental maintenance...
This $380,546 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define how post-transcriptional regulation of RNA shapes gene expression programs that support the function of spermatogonial stem and progenitor cells in the mouse model. The key research objectives are: 1) Investigating how the RNA-binding protein DAZL enhances retinoic acid-mediated changes in transcription and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $785,000.00 over approximately 5 years (Aug 1, 2024 - May 31, 2029) to Rutgers, The State University in Piscataway, NJ to conduct research on RNA-mediated chromatin regulation and transgenerational epigenetic inheritance in the model organism C. elegans. The key objectives of this research project are to: 1) investigate the function and...