The National Institute of General Medical Sciences (NIGMS) has awarded a $454,717 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Trustees of Columbia University in the City of New York to study the regulation of neural progenitor genome dynamics. The 5-year grant, with an effective date of July 1, 2024, will support the investigation of how the three-dimensional organization of the neural progenitor genome contributes to gene expression and cell identity specification during brain development. The researchers will profile genome-wide chromatin interactions in neural progenitors at different developmental stages and examine the role of nuclear factors in coordinating the timing of genome reorganization. This work aims to provide new mechanistic insights into how changes in genome structure impact the specification of neural cell identities.
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